Abstract Background Appropriate drug distribution is needed for effective treatment of brain metastases and leptomeningeal carcinomatosis. Lack proper bioavailability in the CNS contributes to poor outcome these patients. EnClear Therapies has developed a device delivering intrathecal therapeutics utilizing active control CSF flow through an external pump. Herein, we look at delivery methotrexa...

BACKGROUND Intrathecal catheter placement has long-term therapeutic benefits in the management of chronic, intractable pain. Despite the diverse clinical applicability and rising prevalence of implantable drug delivery systems in pain medicine, the spectrum of complications associated with intrathecal catheterization remains largely understudied and underreported in the literature. OBJECTIVE ...

The treatment of meningitis is a complex issue when it comes to multi-resistant antibiotic (ATB) bacteria, limiting the drug options that can cross blood-brain barrier and effectively reach subarachnoid space. impact on effectiveness therapeutic arsenal available, due indiscriminate use antibacterial global scale, increases chances failure initial empirical persistence despite culture targeting...

BACKGROUND Use of intrathecal admixtures is widespread, but compounding these is sometimes challenging and may result in errors and complications causing super-potency or sub potency adverse events in patients or malfunctions in the pump itself. OBJECTIVE The purpose of this study is to evaluate the accuracy of compounding of intrathecal admixtures through a prospective, systematic quantitati...

In 12 consecutive unselected patients admitted to a consultant maternity unit one single injection of subarachnoid morphine sulphate 1.5 mg abolished pain during the first stage of labour. Pain in the second stage was abolished in four patients and lessened in three. During the early puerperium, pain at the site of the episitotomy was much reduced. Side effects included itching of the face, nau...

OBJECTIVES Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model...