BACKGROUND Reticuloendothelial system function is impaired in humans receiving lipid regimens. AIMS To evaluate the effects of long term administration of long chain triglyceride emulsions on reticuloendothelial system function. METHODS Splenic function and tuftsin activity were measured in 20 patients on intravenous nutrition for intestinal failure, 20 patients with Crohn's disease who wer...

BACKGROUND A prospective randomized study was performed to investigate the validity of intravenous carnitine administration during postoperative parenteral nutrition (PN) with lipid emulsion. METHODS Patients undergoing surgery for gastric or colorectal cancer were enrolled in the study and were randomly divided into two groups (n = 8 in each group): 1) group L, who received a peripheral PN (...

A FEBRILE response to intravenous fat emulsion is the most frequent untoward side effect following short-term infusions. Though this side effect is probably not now common or severe enough to limit the clinical usefulness of intravenous fat emulsion, an understanding of its mechanism is important. One hypothesis offered is that the fever is a result of rapid metabolism of the infused fat with t...

Cryptococcal meningitis (CM) is a common cause of death among HIV infected patients in developing countries, especially in sub-Saharan Africa. In this observational HIV cohort study in a resource-limited setting in India, we compared the standard two-week intravenous amphotericin B deoxycholate (AmBd) (Regimen I) with one week of intravenous AmBd along with daily therapeutic lumbar punctures an...

Two murine-derived anti-methamphetamine monoclonal antibodies were studied as potential pharmacokinetic antagonists of (+)-methamphetamine self-administration by rats. Intravenous administration of a 1 g/kg dose of the lower affinity [antibody equilibrium dissociation constant (K(d)) = 250 nM] monoclonal antibody (mAb) designated mAb6H8, 1 day before the start of several daily 2-h self-administ...