OBJECTIVE GH-producing pituitary adenomas display two distinct morphological patterns of cytoplasmic GH-containing secretory granules, namely the densely and sparsely granulated somatotroph adenoma subtype. It is unknown whether these morphological variants reflect distinct pathophysiological entities at the molecular level. METHODS In 28 GH-producing adenoma tissues from a consecutive set of...

Attributes of both the viral glycoprotein and its cellular receptor play key roles in determining the outcome of infection. This body of work endeavors to illustrate how these two components influence the efficiency of virus infection in in vitro and in vivo systems with an emphasis on characterizing the transduction capacity of a novel entry-targeting glycoprotein. In previous work, the Molone...

The genus Berthelotia DC. (presently a synonym of the accepted name Pluchea Cass.), Asteraceae, Inuleae has been regarded as comprising two species, B. lanceolata and sericea (Nutt.) Rydb. It honors French naturalist Sabin Berthelot (1794–1880) for his contribution to studies flora fauna Canary Islands. Under leadership Philip Webb (1793–1854), co-authored most important work pertinent natural ...

The diagnostic value of somatostatin receptor scintigraphy (SRS) in detecting tumors has been assessed in a number of studies. We present a 30-year-old female with a history of eight months cough and left shoulder pain. Radiologic evaluation showed pulmonary mass and hepatic lesions, which were pathologically diagnosed as neuroendocrine carcinoma. 99mTc-octreotide scan demonstrated that the pul...

UNLABELLED The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors has been increasing over the past 3 decades. Because of high densities of somatostatin receptors (sstr)--mainly sstr-2--on the cell surface of these tumors, (111)In-diethylenetriaminepentaacetic acid-octreotide scintigraphy has become an important part of clinical management. (18)F-radiolabeled analogs with ...

Abstract Funding Acknowledgements Type of funding sources: None. Backgrounds Somatostatin receptor (SSTR) based positron emission tomography/computed tomography (PET/CT) is a novel approach for detecting myocardial inflammation and, consequently, cardiac sarcoidosis (CS). However, the diagnostic performance SSTR PET/CT was only evaluated in small studies. Purpose To evaluate clinical diagnosing...

Somatostatin receptor scintigraphy (SRS) is positive in approximately 75% of all patients with neuroendocrine gastroenteropancreatic tumours. This study aimed to identify specific somatostatin receptor (sstr) subtypes, which are responsible for the in vivo binding of the widely used somatostatin analogue, octreotide in human neuroendocrine gastroenteropancreatic tumours. Twelve patients underwe...

Asymmetric threats pose increasing challenges to combatant commanders in Stability, Security, Transition, and Reconstruction (SSTR) Operations. Threats once confined to littoral waters now extend out to the green water theater. Many NATO countries operate their post Falkland war built frigates in these missions, in which lightly armed small, agile and fast craft are often encountered. This stud...