BACKGROUND Iodine deficiency in infants can damage the developing brain and increase mortality. Present recommendations state that oral iodised oil should be given to breastfeeding mothers to correct iodine deficiency in infancy when iodised salt is not available, and that direct supplementation should be given to infants who are not being breastfed or receiving iodine-fortified complimentary f...

We evaluated the effectiveness of a 1.6% phenol-based teat dip using both a teat skin assay and natural exposure field trial. A teat skin assay was conducted to ascertain the concentration of phenol + phenate to be used in the field study. One percent and 0.5% iodine, and 0.5, 1.1, and 1.6% phenol + phenate were compared using Escherichia coli and Staphylococcus aureus. Logarithmic reductions f...

131-radioiodine has been widely used as an effective radionuclide for treatment of patients with thyroid diseases. The purpose of this study was to investigate the genotoxic effects of iodine-131 in human cultured lymphocytes. Whole blood samples from human volunteers were incubated with iodine-131 (10, 50, 100 µCi/1.5ml) for 2 h. The lymphocytes were mitogenically stimulated to allow for evalu...

BACKGROUND The thyroid hormone milieu is of crucial importance for the developing fetus. Pregnancy induces physiological changes in thyroid homeostasis that are influenced by the iodine status. However, longitudinal studies addressing thyroid function during pregnancy and after delivery are still lacking in mild-to-moderate iodine-deficient populations. Here we characterize the serum parameters...

BACKGROUND Iodine deficiency is a global public health problem, and estimates of the extent of the problem were last produced in 2003. OBJECTIVES To provide updated global estimates of the magnitude of iodine deficiency in 2007, to assess progress since 2003, and to provide information on gaps in the data available. METHODS Recently published, nationally representative data on urinary iodin...

OBJECTIVE Denmark was an area of iodine deficiency, and mandatory iodine fortification of table salt and salt in bread (13 p.p.m. iodine) was initiated in 2000/2001. The Danish investigation on iodine intake and thyroid disease (DanThyr) is the monitoring of the iodine fortification program. DESIGN AND METHODS DanThyr consists of three main parts: a study of population cohorts initialized bef...

1201 To the Editor: One cannot deny the importance of goiter assessment in estimating the magnitude of iodine deficiency worldwide in previous decades. While a number of relatively rare pathologic disorders can result in an enlarged thyroid, when the prevalence of goiter is common in a population (.5%), this has most often been the result of inadequate iodine in the diet. A recent article and e...

In that year, 1989, the Executive Director of the International Council for Control of Iodine Deficiency Disorders (that is a very impressive title to say the least), Basil S. Hetzel, published a book entitled The Story of Iodine Deficiency. In that book, goiter and cretinism were the only two aspects of iodine deficiency discussed. One would assume that the experts on human requirements for io...

OBJECTIVE To study the effect of salt reduction on iodine status and to determine whether iodine consumption was still adequate after salt reduction in a population where universal salt iodisation is mandatory. DESIGN A substudy of a cluster randomised controlled trial, with schools randomly assigned to either the intervention or the control group. SETTING 28 primary schools in Changzhi, no...

The cytogenetic changes in the thyroid cells of 199 Fischer rats are reported here. Fifty -eight rats were maintained on a normal iodine diet and 141 rats were maintained on an iodinedeficient diet for 7-25 months. Rats were sacrificed in groups of two to ten at two-week to one-month intervals; their thyroid cells were grown in cell culture and prepared for chromosomal analyses. An average of 4...