I growth factor I (IGF-I) is a peptide which is involved in the regulation of glucose hemostasis, stimulates bone growth, cell differentiation, and metabolism. Obesity may cause structural and functional changes in the heart even in the absence of hypertension and organic heart disease. The IGF-I may play an important role in the development of cardiovascular diseases.1 Due to the interference ...

microRNAs play an important roles in cell growth, differentiation, proliferation and apoptosis. They can function either as tumor suppressors or oncogenes. We found that the overexpression of miR-192 inhibited cell proliferation in A549, H460 and 95D cells, and inhibited tumorigenesis in a nude mouse model. Both caspase-7 and the PARP protein were activated by the overexpression of miR-192, thu...

Metastasis is one of the causes of cancer death. Functions and mechanisms of microRNAs (miRNAs) involved in hepatocellular carcinoma (HCC) metastasis are largely unknown. Here, a miRNA microarray analysis was performed in MHCC-97L, MHCC-97H and HCC-LM3 cells with gradually increasing metastatic potential to disclose crucial miRNAs involved in HCC metastasis. miR-192 expression decreased and neg...

Elevated p53 expression is associated with several kidney diseases including diabetic nephropathy (DN). However, the mechanisms are unclear. We report that expression levels of transforming growth factor-β1 (TGF-β), p53, and microRNA-192 (miR-192) are increased in the renal cortex of diabetic mice, and this is associated with enhanced glomerular expansion and fibrosis relative to nondiabetic mi...

Methods The sequence, IR-rttfl, performs realtime turboflash acquisition after an inversion pulse to capture the recovery of inverted magnetization. It is immune to T1 unrelated issues (e.g., field inhomogeneity). Diastolic images (about 12) are selected for T1 calculation using [4]. A trigger delay (about 300-400 ms) is applied before the inversion pulse so that initial magnetization recovery ...

The glass transition temperatures of AgPO3 have been reported to lie in the 163 Tg 192 °C range. These results are typical when precursors are processed at laboratory ambient. In the present work, we show that if precursors are handled in a dry ambient environment, the Tg’s steadily increase in the 181 2 Tg 254 2 °C range as the relative humidity of the ambient environment decreases. The glass ...

A hybrid toxin composed of ricin A chain and a monoclonal antibody directed against the rat nerve growth factor (NGF) receptor (192-IgG) was prepared using the heterobifunctional cross-linking agent N-succinimidyl-3-(2-pyridyldithio)-propionate and purified by affinity chromatography. Characterization studies showed that the hybrid, 192-s-s-A, displaced bound 125I-labeled 192-IgG from rat super...