Platelet-rich plasma (PRP) contains a variety of cytokines, some of which ameliorate oX-LDL (oxidized low-density lipoprotein)-induced endothelial cell (EC) injury. Therefore, we hypothesized that PRP might alleviate oX-LDL-induced injury. Methodology Human umbilical vein endothelial cells (HUVECs) were divided into four groups: a PPP (platelet-poor plasma) group, an oX-LDL group, an oX-LDL+P...

The OX-40 molecule is expressed on the surface of recently activated T lymphocytes. The presence of OX-40 on CD4+ T cells was analyzed in a rat haplo-identical (parental --> F1) bone marrow transplant model of acute graft-versus-host disease (aGVHD). Increased numbers of activated CD4+ T cells that expressed the OX-40 antigen were detected in peripheral blood soon after transplantation before t...

Abstract Introduction Despite the known cytotoxic and hepatotoxic effects of most common chemotherapy drugs, their use in context liver regeneration as part antitumor treatment is controversial. Methods Thirty-six WAG/RijHsd rats were induced to selective portal ligation 50% hepatic parenchyma, divided into 3 experimental groups. 72 hours before, two groups treated with 5-Fluorouracil (50mg/kg)...

Background: Considerable evidence suggests that oxidative stress affects diabetes mellitus (DM) and contributes to its complications. Vitamin D has been shown to possess antioxidant properties. The aim of this study was to determine the association between serum levels of calcifediol (25-OH-D), an indicator of vitamin D status, and lipid profiles with oxidative stress in patients with type 2 di...

We examined the effects of human low density lipoprotein (LDL) and oxidized LDL (Ox-LDL) on the cytotoxic activity of Asp-hemolysin from Aspergillus fumigatus Fresenius-Muramatsu strain to mouse peritoneal macrophages (M phi). The inhibitory effects of LDL and Ox-LDL on the cytotoxic activity of Asp-hemolysin to M phi increased in a dose-dependent manner, and the effect of Ox-LDL was greater th...

To investigate the efficacy in occluding dentin tubules of a modified calcium phosphate based solution supplemented with fluoride and zinc ions (CaP), dentine discs were separately treated with CaP and certain common desensitizing agents including potassium oxalate solution (OX), modified oxalate solutions supplemented with calcium ions (OX/Ca) or phosphate ions (OX/P) for 8 minutes, followed b...

Introduction Patients with primary nephrotic syndrome (PNS) were reported to exhibit the evident imbalance between number of Th17 and Treg cells in their peripheral blood monocytes (PBMCs), which might be immunological basis disease. Material methods 40 PNS patients 42 healthy individuals recruited this study. FCM assay was used observe levels cells. Results The Treg/Th17 ratio evidently decrea...

Modified high density lipoprotein (HDL) has been suggested to modulate endothelial expression of proinflammatory genes. Since oxidised HDL (Ox-HDL) has been found in atheromatous plaques and receptors for modified HDL are present on endothelial cells, we investigated the effect of Ox-HDL3 on the expression of Cox-1 or Cox-2. Ox-HDL3, increased Cox-2 mRNA and protein expression in endothelial ce...

Background: There is evidence that CD36 promotes foam cell formation through internalizing oxidized LDL (ox-LDL) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. In addition, CD36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of the present study was to evaluate and compare the effect of ...

We have shown that transferred lysophosphatidylcholine (lysoPC) from oxidized low-density lipoprotein (OxLDL) to endothelial surface membrane activates protein kinase C (PKC) in endothelial cells, suggesting that Ox-LDL could alter endothelial functions through PKC activation. The purposes of the present study were to examine whether the endothelial susceptibility to polymorphonuclear leukocyte...