Iron overload in liver is associated with the oxidative damage of protein, lipid and nucleic acids which in turn manifests several human diseases. The present study was aimed to evaluate the amending effect of 70% methanol extract of Hemidesmus indicus root (HIME) on iron overload induced liver injury. Iron overload was induced by intraperitoneal administration of iron-dextran into mice. Mice a...

Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the most common genetic disorders among Caucasians. Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes. Here, we show that a Cre-loxP-mediated liver-specific disruption of SMAD4 results in markedly decreased hepcidin expression and accumulation of iron in many orga...

Iron, an essential nutrient causes serious diseases in deficient state. But more serious events occur due to the toxicity of iron overload and this leads to morbidity and mortality of a significant population of the world. Chronic iron poisoning can occur due to daily high dietary iron intake, chronic liver disease, rare genetic disorders of iron metabolism, etc. But the commonest causes of sev...

Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the most common genetic disorders among Caucasians. Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes. Here, we show that a Cre-loxP-mediated liver-specific disruption of SMAD4 results in markedly decreased hepcidin expression and accumulation of iron in many orga...

The high incidence of cardiomyopathy in patients with hemosiderosis, particularly in transfusional iron overload, strongly indicates that iron accumulation in the heart plays a major role in the process leading to heart failure. In this context, iron-mediated generation of noxious reactive oxygen species is believed to be the most important pathogenetic mechanism determining cardiomyocyte damag...

Iron may accumulate in excess due to a mutation in the HFE gene that upregulates absorption or when it is ingested or infused at levels that exceed the body's ability to clear it. Excess iron deposition in parenchymal tissue causes injury and ultimately organ dysfunction. Diabetes mellitus and hepatic cirrhosis due to pancreas and liver damage are just two examples of diseases that result from ...

Many patients with bone marrow failure syndromes need frequent transfusions of red blood cells, and most of them eventually suffer from organ dysfunction induced by excessively accumulated iron. The only way to treat transfusion-induced iron overload is iron chelating therapy. However, most patients have not been treated effectively because daily/continuous administration of deferoxamine is dif...

Thalassemias are a geographically widespread group of genetic hemoglobinopathies characterized by defective globin production and hemolytic anemia [1]. Thalassemic patients are frequently transfusiondependent and this, in addition to heightened gastrointestinal avidity for iron, creates a propensity for iron overload [1]. Infection is a major cause of morbidity in thalassemic patients and is se...

Patients with transfusion-dependent myelodysplastic syndromes (MDS) have an increased risk of cardiac events, due to both chronic anemia and iron overload. Here, we report the recovery of cardiac function after an intensive iron chelation therapy in a MDS patient who had developed heart failure due to iron overload.

Blood transfusion plays a prominent role in the management of patients with sickle cell disease (SCD), but causes significant iron overload. As transfusions are used to treat the severe complications of SCD, it remains difficult to distinguish whether organ damage is a consequence of iron overload or is due to the complications treated by transfusion. Better management has resulted in increased...