ownload ic oxide (NO), which plays a role in the posttranslational modification of proteins, exhibits tumoricidal y. However, the mechanism remains largely unclear. We investigated whether the regulation of insulin resubstrate (IRS)-1 protein expression and insulin/insulin-like growth factor (IGF) signaling by NO is inin the proliferation and invasion of pancreatic cancer cells. NO donor inhibi...

OBJECTIVE To assess the relation of the metabolic insulin resistance syndrome (M-IRS) with coronary heart disease (CHD) in Pakistani patients. SUBJECTS 200 patients with angiographic disease (CHD(+)) matched with 200 patients with chest pain without occlusive disease (CHD(-)). DESIGN Prospective case-control study. SETTING Tertiary referral cardiology unit in Pakistan. RESULTS M-IRS was...

Insulin resistance is associated with cardiovascular disease. Impaired insulin receptor substrate (IRS)-mediated signal transduction is a major contributor to insulin resistance. Recently, IRS-1 phosphorylation at serine 307 by stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) has been highlighted as a molecular event that causes insulin resistance. We investigated IRS-1-mediat...

Channel estimation is a practical challenge for intelligent reflecting surface (IRS) aided wireless communication. As the number of IRS elements or IRS-aided users increases, channel training overhead becomes excessively high, which results in long delay and low throughput data transmission. To tackle this challenge, we propose paper new anchor-assisted approach, where two anchor nodes, namely ...

Insulin receptor substrates (IRSs) play central roles in insulin/insulin-like growth factor (IGF) signaling and mediate a variety of their bioactivities. IRSs are tyrosine-phosphorylated by activated insulin receptor/IGF-I receptor tyrosine kinase in response to insulin/IGF, and are recognized by signaling molecules possessing the SH2 domain such as phosphatidylinositol 3-kinase (PI3K), leading...

Glucose-6-phosphatase catalyzes the terminal step in the gluconeogenic and glycogenolytic pathways. In HepG2 cells, the maximum repression of basal glucose-6-phosphatase catalytic subunit (G6Pase) gene transcription by insulin requires two distinct promoter regions, designated A (located between -231 and -199) and B (located between -198 and -159), that together form an insulin response unit. R...

Serine and threonine phosphorylation of IRS-1 (insulin receptor substrate-1) has been reported to decrease its ability to be tyrosine-phosphorylated by the insulin receptor. Insulin itself may negatively regulate tyrosine phosphorylation of IRS-1 through a PI3K (phosphoinositide 3-kinase)-dependent feedback pathway. In the present study, we examined the regulation and role of IRS-1 serine phosp...

The Arg insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic -cell stimulus-coupled insulin secretion and survival. We analyzed the relations between type 1 diabetes and the Arg IRS-1 variant. The frequency of the IRS-1 Arg variant was investigated in two independent sets of unrelated patients: a case-control study and a collection of type 1 diabetes s...