background and objective : sleep deprivation (sd) is caused by a host of reasons and has numerous consequences on cardiac system. in this study, we aimed to assess the preconditioning effects of acute sd on ischemia (is)-induced ventricular arrhythmias in isolated rat hearts. materials and methods : male wistar rats randomly were placed into the four groups: is-group, acute sd group, control gr...

background & target: ischemia reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. in this study, the effect of pentoxyfylline on bcl2 gene expression changes and cell injury in kidney of rat following ischemia reperfusion were evaluated.methods: in this experimental study, 20 male wistar rats with average weight of...

Abstract Background Primary graft dysfunction (PGD) remains a major obstacle after lung transplantation. Ischemia–reperfusion injury is known contributor to the development of PGD following We developed novel approach assess impact increased pulmonary blood flow in large porcine single-left transplantation model. Materials Twelve left transplants were divided two groups ( n = 6, low- (LF) and h...

Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction proteins, development muscle contracture etc. It was shown that hydrogen sulfide (H2S) and precursor its synthesis amino acid L-cysteine provided cardioprotective effect against ischemiarepe...

To explore the protective effect of bilobalide on pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. simulate ischemia-reperfusion condition, was The cells were divided into control, and deprivation/ reperfusion+bilobalide groups. viability, proliferative capacity, malondialdehyde level, superoxide dismutase apoptosis, Wnt1 protein level nuclear beta-cateni...

Acute myocardial infarction (AMI) is the leading cause of death, morbidity, and health costs worldwide. In AMI, a sudden blockage blood flow causes ischemia cell death. Reperfusion after has paradoxical effects may exacerbate injury, process known as ischemic reperfusion injury. this work we evaluated lipidome isolated rat hearts, maintained in controlled perfusion (CT), undergoing global (ISC)...

3 Introduction 3 Pathophysiological features of reperfusion injury 4 Metabolic changes in myocardial ischemia-reperfusion 7 Oxidative stress in myocardial ischemia-reperfusion 9 Types of antioxidants 11 Role of antioxidants in myocardial ischemia-reperfusion injury 12 Hypothesis 15 Hypothesis 1: Xanthine oxidase inhibitor can protect against myocardial ischemia-reperfusion injury. 15 Hypothesis...

Significance: Intraoperative parameters of renal cortical microperfusion (RCM) have been associated with postoperative ischemia/reperfusion injury. Laser speckle contrast imaging (LSCI) could provide valuable information in this regard the advantage over current standard care being a non-contact and full-field technique. Aim: Our study aims to validate use LSCI for visualization RCM on ex vivo ...

OBJECTIVES The clinical significance of ischemia/reperfusion of the lower extremities demands further investigation to enable the development of more effective therapeutic alternatives. This study investigated the changes in the vascular reactivity of the rabbit femoral artery and nitric oxide metabolites under partial ischemia/ reperfusion conditions following cilostazol administration. METH...