BACKGROUND Oxidative stress plays a major role in the biochemical and pathological changes associated with myocardial ischemic-reperfusion injury (IRI). The need to identify agents with a potential for preventing such damage has assumed great importance. Chronic oral administration of raw garlic has been previously reported to augment myocardial endogenous antioxidants. In the present study, th...

Studies suggest that biological sex influences susceptibility to kidney diseases with males demonstrating greater risk for developing ischemic acute injury (AKI). Sex-related differences in mitochondrial function and homeostasis exist, likely contributing sexual dimorphism injury, but the mechanisms are not well characterized. Our observations reveal lower baseline expression of Sirtuin-3 (Sirt...

Background: Paraplegia is a major devastating and unpredictable complication of spinal cord ischemic reperfusion injury (SC-IRI). Ischemic preconditioning (IPC) is a procedure whereby a brief episode of non-lethal ischemia to an organ produces protection against subsequent detrimental ischemic-reperfusion insult to that organ. It has been shown that IPC may not only induce a local protective ef...

Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality. Given the importance of microRNAs (miRNAs) in regulating gene expression, we examined expression profiles of miRNAs following renal IRI. Global miRNA expression profiling on samples prepared from the kidneys of C57BL/6 mice that underwent unilateral warm ischemia revealed nine miRNAs (miR-21, miR-20a...

BACKGROUND The effect of paricalcitol on renal ischemia-reperfusion injury (IRI) has not been investigated. We examined whether paricalcitol is effective in preventing inflammation in a mouse model of IRI, and evaluated the cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) pathways as a protective mechanism of paricalcitol. METHODS Paricalcitol (0.3 μg/kg) was administered to male C57BL/6 ...

Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Here we review clinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analys...

Since the beginning of transplantation era, ischemia/ reperfusion injury (IRI) has remained one of the most serious pitfalls of the procedure. Although thousands of scientific studies and analyses have been published, and mechanisms of the injury recognized and described, the most serious step forward to avoid the IRI was Geoffrey Collins' and Folkert Belzer's invention of two different intrace...

Abstract Background Diabetes clinical trials have shown SGLT inhibition improves cardiovascular outcomes, yet the mechanism is not fully understood. Hyperglycemia a common finding in diabetic and non-diabetic patients presenting with ACS powerful predictor of prognosis mortality. The role hyperglycemia ischemia-reperfusion injury (IRI) understood, whether Sodium Glucose Co-Transporter 1 (SGLT1)...

Renal ischemia-reperfusion injury (IRI) induces local inflammation leading to kidney damage. Since pentoxifylline (PTX) and steroids have distinct immunomodulatory properties, we aimed to evaluate for the first time their combined use in IRI-induced acute kidney injury (AKI) and chronic kidney disease (CKD) in rats. In two experiments, PTX (100 mg/kg body weight subcutaneously) was administered...

Hepatic ischemia reperfusion injury (IRI) is an inevitable clinical problem for liver surgery. Polyethylene glycols (PEGs) are water soluble nontoxic polymers that have proven their effectiveness in various in vivo and in vitro models of tissue injury. The present study aims to investigate whether the intravenous administration of a high molecular weight PEG of 35 kDa (PEG 35) could be an effec...