Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis which an important public health problem in Morocco. The conventional approaches employed to fight TB are good nutrition, Bacillus Calmette-Guerin (BCG) vaccination, anti-TB therapy. World Health Organization (WHO) recommends combination treatment of four drugs for two months (isoniazid (INH), rifampicin, pyrazinami...

In this work poly eriochrome black T (EBT) was electrochemically synthesized on the glassy carbon electrode as electrode modifier. On the modified electrode, voltammetric behavior of isoniazid (INH) was investigated. The poly (EBT)-modified glassy carbon electrode has excellent electrocatalytic ability for the electrooxidation of isoniazid. This fact was appeared as a reduced overpotential of I...

Isoniazid (INH) is a key antitubercular agent, which exhibits poor chemical stability in the solid state associated with hydrazide group. Cocrystallization Gentisic Acid having antioxidant activity, may produce forms improved pharmaceutical properties. The complementary nature of functional groups isoniazid and chosen coformer resulted success for cocrystal formation. Cocrystal (INH-Gentisic ac...

Isoniazid (INH) is a first-line drug for tuberculosis control; the side effects of INH are thought to be associated with its metabolism, and this study was designed to globally characterize isoniazid metabolism. Metabolomic strategies were used to profile isoniazid metabolism in humans. Eight known and seven novel INH metabolites and hydrazones were identified in human urine. The novel products...

Objective of the resent study was to determine the effect of ofloxacin (OXC) on the pharmacokinetics of isoniazid (INH). Five healthy volunteers aged 18 – 39 years participated in this study after an informed consent. The study was carried out in two phases with an interval of one-week drug wash out period in between phases. In phase one (INH alone), each subject received 300mg of isoniazid (IN...

In this study Isoniazid (INH) as one of the first line drugs in treatment of Tuberculosis was investigated to be loaded in Solid Lipid Nanoparticles (SLNs) for reducing hepatotoxicity as well as prolonging drug release. High shear homogenization method was performed to prepare INH SLNs. To compare biodistribution of INH before and after loading in SLNs, INH was labeled by Technetium 99 (Tc99) a...

objective(s) isoniazid (inh) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. resistance to inh is mediated mainly by mutation in katg gene that is coded for the catalase enzyme. the proportional method for detection of inh-resistance is time consuming due to the slow...

Pharmacokinetic characteristics of INH are presented. Adverse effects and toxicity caused by INH has been reviewed under the headings of neuropathy and seizures, hepatotoxicity, rhabdomyolysis, agranulocytosis, acidosis and other adverse drug reactions. Cases of poisoning by INH have been mentioned independently. Few case reports indicating symptoms of intoxication and the mechanism of toxicity...