Addition, together with antigen, of compound I.C.I. 74917 (0.1 pg/ml) to chopped sensitized lung, preincubated with DL-isoprenaline for 3 min, resulted in extra inhibition of histamine release as seen in Fig. 2(a). Comparison of the total inhibition with individual values for compound I.C.I. 74917 and isoprenaline show that there is addition rather than synergism, i.e. if compound I.C.I. 74917 ...

The cardiovascular and hypokalaemic effects of equal doses of inhaled fenoterol, isoprenaline and salbutamol were compared in eight healthy male volunteers, in a double blind, placebo controlled study. Increasing doses of 400, 600, and 800 micrograms were given from a metered dose inhaler at 15 minute intervals, followed by measurements of heart rate, blood pressure, total electromechanical sys...

The present study was primarily designed to explore various methodological aspects related to organ bath experiments evaluating human detrusor relaxation by the β-adrenoceptor agonist isoprenaline. Data are based upon a series of 30 consecutive patients, and this cohort was also used to explore possible effects of gender and age. KCl-induced contraction was related to strip length but not weigh...

The beta-receptor stimulating effect of isoprenaline on the spontaneous activities of the guinea-pig taenia coli was investigated in the presence of an alpha-receptor blocking agent, phentolamine (2 X 10(-6) M). Substitution of the external Naion with Li, choline, tris-hydroxymethyl aminomethane or Kion greatly reduced the inhibitory effect of isoprenaline. A treatment with ouabain (4 X 10(-6) ...

Mechanisms underlying beta-adrenoceptor (beta-AR)-mediated vascular relaxation were studied in the isolated rat abdominal aorta. In the endothelium-denuded helical preparations, a non-selective beta-AR agonist isoprenaline elicited a concentration-dependent relaxation. In the absence of beta-AR antagonists, isoprenaline-induced relaxation was not practically affected by an adenylyl cyclase inhi...

The mechanism of isoprenaline exerting its effects on cardiac pacemaking and driving in sick sinus syndrome is controversial and unresolved. In this paper, mathematical models for rabbit sinoatrial node cells were modified by incorporating equations for the known dose-dependent actions of isoprenaline on various ionic channel currents, the intracellular Ca²⁺ transient, and i(Na) changes induced...

Milner, A. D., and Ingram, D. (1971). Archives of Diseases in Childhood, 46, 502. Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma. The bronchodilator and cardiac effects of 0-5% isoprenaline, 2 5% orciprenaline, and 0-5% salbutamol, and a placebo solution inhaled as a nebulized mist from a Wright nebulizer were compared with the help of 12 as...

While evidence has been presented for the receptor-mediated activation of phospholipases A2, C and D, the activation of phospholipase A1 subsequent to receptor activation has not been established. Phospholipase A1-catalysed hydrolysis of 1-palmitoyl-2-linoleoyl-glycerophosphoethanolamine (GPE) by guinea-pig heart microsomes was stimulated 40-60% by isoprenaline. This isoprenaline-mediated incre...

Electrical activity was recorded intracellularly from the muscle cell of guinea-pig taenia caeci in Locke solution. Membrane potential was -46.4 mV, and spike potentials were discharged spontaneously. Isoprenaline (3 microM) hyperpolarized the membrane and suppressed the spike discharge. The hyperpolarization by isoprenaline was increased at low K (2 mM), while decreased at high K (11.8, 29.5, ...

Cryptotanshinone is an active ingredient of Salvia miltiorrhiza that has been used in traditional Chinese medicine for treating cardiovascular disorders. Thus, we investigated the effects of cryptotanshinone on cardiac fibrosis induced by isoprenaline and examined whether cardiac matrix metalloproteinase (MMP)-2 is involved in this process. Male C57BL/6 mice received a daily injection of 0.9% s...