Non-breaking tsunami waves run-up on steep slopes can cause severe damages to coastal structures. The estimation of the wave run-up rate caused by tsunami waves are important to understand the performance and safety issues of the breakwater in practice. In this paper, an Incompressible Smoothed Particle Hydrodynamics method (ISPH) method was utilized for the 2DV numerical modeling of nonli...

A drawback of the Smoothed Particle Hydrodynamics (SPH) method is its computational effort. An intuitive way to reduce the calculation time, is to use SPH only in parts of the problem domain where it is necessary, e.g. in a region where interfaces are present, because of the advantages of SPH for multiphase flow. In other parts of the problem domain, e.g. in a region of simple flow, a cheap met...

Camptothecin is an anti-cancer monoterpene indole alkaloid. The gene encoding 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (designated as CaHDR), the last catalytic enzyme of the MEP pathway for terpenoid biosynthesis, was isolated from camptothecin-producing Camptotheca acuminata. The full-length cDNA of CaHDR was 1686 bp encoding 459 amino acids. Comparison of the cDNA and genomic...

Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for the biosynthesis of terpenes. Although their biosynthesis by means of mevalonate has been studied in detail, a second biosynthetic pathway for their formation by means of 1-deoxy-D-xylulose 5-phosphate has been discovered only recently in plants and certain eubacteria. Earlier in vivo experiments with re...