Malignant breast lesions in x–ray mammograms are often characterised by abnormal patterns of linear structures. Architectural distortions and stellate lesions are examples of patterns frequently presenting with an appearance of radiating lines. Attempts to automatically detect these abnormalities have generally concentrated on features of known importance, such as radiating linear structure con...

Liver fibrosis represents a significant health problem worldwide for which no effective therapy exists. A great deal of research has been carried out to understand the molecular mechanisms responsible for the development of liver fibrosis. Activated stellate cells are the primary cell type responsible for the production of collagen I, the key protein involved in the development of liver fibrosi...

Stellate ganglion stimulation in the anesthetized, open-chest dog consistently resulted in the generation of pressure differences which averaged 20 mm Hg across the infundibular region of the right ventricle. Before stimulation, peak systolic pressures in the sinus and conus were closely matched. Peak sinus pressure showed ah average increase of 184 and 162% during stimulation of the left and r...

Cholera toxin B subunit conjugated to saporin (SAP, a ribosomal inactivating protein that binds to and inactivates ribosomes) was injected in both stellate ganglia to evaluate the physiological response to targeted ablation of cardiac sympathetic neurons. Resting cardiac sympathetic activity (cardiac sympathetic tonus), exercise-induced sympathetic activity (heart rate responses to graded exerc...

The effects of unilateral right, unilateral left, and bilateral stellate stimulation on ventricular refractory periods at sites of overlapping cardiac sympathetic innervation were studied in 11 pentobarbital anesthetized dogs. The stellates were stimulated with 10 Hz pulses 4 msec in duration with intensities strong enough to produce T wave changes in a vertical ECG lead and just below the inte...

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells. Although the stellate cells are thought to contribute to tumorigenesis, metastasis and drug resistance of PDAC, the signaling events involved in activation of the stellate cells are not well defined. Functioning as tr...

Previous studies evaluating the mechanism of renal HCO-3 reabsorption have assumed equilibrium between systemic arterial blood and tubular fluid PCO2. We have recently reported that the PCO2 in proximal and distal tubular fluid as well as the stellate vessel significantly exceeded arterial PCO2 by 25.9 +/- 0.92 mm Hg. The purpose of this study was to determine directly, for the first time, pH, ...

SIOLOGY 1981; 54:421–3 35. Haug O, Draper WL, Haug SA: Stellate ganglion blocks for idiopathic sensorineural hearing loss. Arch Otolaryngol 1976; 102:5– 8 36. Liu F, Xu G, Liu Z, Zhao Y, Lv X, Wang J: The effects of stellate ganglion block on visual evoked potential and blood flow of the ophthalmic and internal carotid arteries in patients with ischemic optic neuropathy. Anesth Analg 2005; 100:...

In immunohistochemical reactions against glutamic acid decarboxylase (GAD), gamma-aminobutyric acid (GABA) and glycine (Gly), neurons in the mouse cerebellum showed the following reactivities: (1) the dendrites and cell bodies of the Purkinje cells were only GAD-positive, but their axonal terminals were GABA- and GAD-positive; (2) in both stellate and basket cells, the cell bodies and terminals...

The effect of liver growth stimulation [using the rodent PXR (pregnane X receptor) activator PCN (pregnenolone-16alpha-carbonitrile)] in rats chronically treated with carbon tetrachloride to cause repeated hepatocyte necrosis and liver fibrogenesis was examined. PCN did not inhibit the hepatotoxicity of carbon tetrachloride. However, transdifferentiation of hepatic stellate cells and the extent...