Background During the last decades, researchers have provided a plethora of therapeutic uses of kaempferol, including anticancer, anti-inflammatory, neuroprotective, anti-oxidative and anti-oestrogenic activities, making kaempferol a valuable compound [1]. However, being a poor water-soluble compound, kaempferol often has insufficient solubility and bioavailability [2].To find a solution for th...

Background and Objective: The rate of survival in acute promyelocytic leukemia (APL) can dramatically improve, if the patients receive all-trans-retinoic acid (ATRA) treatment. However, this drugchr('39')s toxicity is a major problem in APL treatment. Previous researches have demonstrated that phyto-polyphenols such as epigallocatechin gallate (EGCG) and kaempferol cause apoptosis in hematopoie...

The effects of kaempferol on the oxidative and phosphorylative properties of plant mitochondria from potato tubers and etiolated mung bean (Phaseolus aureus Roxb.) hypocotyls were investigated. Kaempferol inhibited the state 3 oxidation rate of malate, NADH, and succinate, but was without effect on the ascorbate-tetramethyl p-phenylenediamine oxidation rate. The inhibition was almost the same w...

in this work, the study of various substituted kaempferol derivatives is presented. the bond dissociation energies (bde) have been calculated using b3lyp level and different basis sets in gas-phase. calculated results show that the bde values of substituted kaempferol range from about 77 to100 kcal/mol, demonstrating that kaempferol is an effective chain-breaking antioxidant that prevents lipid...

previously, we reported that the kaempferol and kaempferol-7- o -glucoside isolated from securigera securidaca showed potent anti-hsv activity. in the present study the anti-hiv-1 activities of kaempferol and kaempferol-7- o -glucoside are investigated at different concentrations (100, 50, 25 and 10 µg/ml) using hiv-1 p24 antigen kit. real-time polymerase chain reaction (rt-pcr) assay was also ...

Kaempferol induces differentiation in partially differentiated colon cancer cells which express low levels of connexin43 protein and connexin43 mRNA (KNC cells). Differentiation was observed as changes in cell morphology and the activity of alkaline phosphatase. Increased differentiation in kaempferol-treated KNC cells correlated with restoration of gap junctional intercellular communication (G...

Previously, we reported that the kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca showed potent anti-HSV activity. In the present study the anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside are investigated at different concentrations (100, 50, 25 and 10 μg/ml) using HIV-1 p24 Antigen kit. Real-time Polymerase chain reaction (RT-PCR) assay was also used...

Kaempferol has been reported to reduce the risk of ovarian cancer, but the mechanism is not completely understood. In this study, we tend to expand our understanding on how kaempferol regulates VEGF expression and angiogenesis in ovarian cancer cells. We timed VEGF secretion, and studied in-vitro angiogenesis by kaempferol treatment. Gene expression was examined by qRT-PCR, ELISA, Western Blott...

Increasing data from epidemiological and in vitro studies show that the isoflavonoids, genistein and daidzein, and the flavonols, quercetin and kaempferol, are protective against postmenopausal bone loss. However, the physiological mechanisms for these effects are not well understood. We now report that kaempferol exerts profound antiosteoclastogenic effects by acting on both osteoblasts and os...

Flavonoids distribution in three algerian Bupleureum (Apiaceae) species has been investigated. Quercetin (1), quercetin 3-rutinoside (2) and isorhamnetin 3-rutinoside (3) were found in the endemic species B. plantagineum Desf. Three kaempferol glycosides, kaempferol 3-glucoside (4), kaempferol 3-galactoside (5), kaempferol 3-rutinoside (6) and three quercetin glycosides, quercetin 3-rutinoside ...