Signaling pathways provide essential information on complex Summary: regulatory processes within the cell. They are moreover widely used to interpret and integrate data from large-scale studies, such as expression or functional screens. We present KEGGViewer a BioJS component to visualize KEGG pathways and to allow their visual integration with functional data. KEGGViewer is an open-source tool...

EGENES is a knowledge-based database for efficient analysis of plant ESTs that was recently added to the KEGG suite of databases. It links plant genomic information with higher order functional information in a single database. It also provides gene indices for each genome. The genomic information in EGENES is a collection of EST-contigs constructed from assembly of expressed sequence tags (EST...

Scientific visualization is a key technology to enhance our understanding of huge masses of omics data, especially for cell-wide, high-throughput measurements of the physiological networks. We have developed a web application that visualizes complex omics data of multiple layers simultaneously, including transcriptome, proteome, and metabolome, onto an integrated pathway diagram derived by conn...

is organized into three sections: pathway information , genomic information, and computational tools. The pathway information section includes searchable pathway maps and orthologue tables of metabolic and regulatory pathways. There are also extensive catalogues of diseases (human), organisms (completely sequenced genomes or chromosomes), cells (cell lineages), enzymes and`compounds'. All of th...

One of the most promising avenues for interpreting large datasets of molecular expression profiles involves pathway-based analysis. Pathways are collection of genes and proteins that perform a well-defined biological task. These pathways have been established through decades of molecular biology research and are collected in a variety of public pathway repositories (KEGG and Reactome Pathway da...

Patients with lymphoma are at high risk of developing venous thromboembolism (VTE). The purpose of the present study was to identify the target gene associated with VTE for patients with lymphoma. Microarray data was downloaded from the gene expression omnibus database (GSE17078), which comprised the control group, 27 normal blood outgrowth endothelial cell (BOEC) samples, and the case group, 3...

Genome-wide association studies (GWAS) with hundreds of żthousands of single nucleotide polymorphisms (SNPs) are popular strategies to reveal the genetic basis of human complex diseases. Despite many successes of GWAS, it is well recognized that new analytical approaches have to be integrated to achieve their full potential. Starting with a list of SNPs, found to be associated with disease in G...

SUMMARY Signaling pathways provide essential information on complex regulatory processes within the cell. They are moreover widely used to interpret and integrate data from large-scale studies, such as expression or functional screens. We present KEGGViewer a BioJS component to visualize KEGG pathways and to allow their visual integration with functional data. AVAILABILITY KEGGViewer is an op...