Objective(s): Vaccination is one of the most effective means to protect humans and animals against brucellosis. Live attenuated Brucella vaccines are considered effective in animals but they may be potentially infectious to humans, so it is vital to improve the immunoprotective effects and safety of vaccines against Brucella. This study was designed to evaluate the immunogenicity of DNA vaccine...

Immune responsiveness to IgG allotypes in the mouse was found to be controlled by an immune response gene Ir-IgG linked to the H-2 locus. This was demonstrated by the analysis of the immune response to BALB/c IgG (gamma2a) myeloma proteins in mice of various H-2 types from five different linkage groups of immunoglobulin heavy chains. Antisera were examined for antibodies to idiotypic (Fab) and ...

The main objective of this study is to analyze the effects sublingual specific immunotherapy and conventional drug therapy on inflammatory factors immune function in children with allergic rhinitis. research subjects were divided into three groups, group A received administration dust mite drops, B routine treatment such as passive intervention topical hormones, antihistamines nasal irrigation ...

Human myeloma are incurable hematologic cancers of immunoglobulin-secreting plasma cells in bone marrow. Although malignant plasma cells can be almost eradicated from the patient's bone marrow by chemotherapy, drug-resistant myeloma precursor cells persist in an apparently cryptic compartment. Controversy exists as to whether myeloma precursor cells are hematopoietic stem cells, pre-B cells, ge...

Objective To discuss the clinical value of immunoglobulin gene rearrangements in the diagnosis of B-cell lymphoma. Methods A total of 209 cases of B-cell lymphomas and 35 cases of reactive lymphoid hyperplasia were selected for DNA extraction and PCR amplification using the BIOMED-2 primer system. Gel electrophoresis of heteroduplexes was used to analyze immunoglobulin gene rearrangements. ...

Background: Scleroderma is a chronic systemic disorder that affects the connective tissues. It is characterized by several immune manifestations, inflammation, vascular damage, and fibrosis. Some of the viral infections with complex mechanisms are involved in the development and progression of many autoimmune diseases, such as scleroderma. The present study aimed to investigate the serological ...

background and aims: human parvovirus b19, a member of the parvoviridae family, with single-stranded dna is a very minute non-enveloped virus. b 19 virus is mostly transmitted via the respiratory tract but some studies have been reported which b19 virus can be transmitted through blood and/or blood products. the aim of this study was to evaluate the prevalence of b19 among blood donors in tehra...

objective: cryptosporidiosis is a parasitic disease that is causing small protozoan genus cryptosporidum and transmission take place through fecal- oral by direct contact or indirectly through food or drink. the aim of this study was detection of anti-cryptosporidum parvum immunoglobulin igg, in newborn balb/c infected with c. parvum. materials and methods: oocysts of c. parvum were obtained f...