Kidney replacement therapy (KRT) is a term used to encompass life-supporting treatments for kidney failure. except transplantation replaces nonendocrine functions in patients with Researchers have noted that dialysis, which one of the most common KRT used, cannot compensate all tasks performed by kidney, and thus ‘Kidney support therapy’ has been suggested be better name. Support function moder...

ABSTRACT Background: Alkaloids from Senna alata leaves implicated as the active constituents of abortifacient are yet to be investigated for their effects on the normal functioning of the maternal liver and kidney. Therefore, the effects of crude alkaloids on some biochemical indices of kidney and liver damage were investigated in pregnant rats. Methods: Pregnant rats were randomized into...

It has been suggested that exposure to organic solvents may have a role in the impairment of kidney function that may progress to kidney failure. However, this has never been evaluated with an appropriate analytical study of the kidney functions of those people who are chronically exposed to these chemicals. This study was designed to measure the kidney function of car painters in the city of M...

BACKGROUND The molecular mechanisms that mediate the ischemia-reperfusion (I/R) injury in kidney are not completely understood. It is also largely unknown whether such mechanisms overlap with those governing the early development of kidney. METHODOLOGY/PRINCIPAL FINDINGS We performed gene expression analysis to investigate the transcriptome changes during regeneration after I/R injury in the ...

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CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibros...

The kidney is a highly vascularized organ that normally receives a fifth of the cardiac output. The unique spatial arrangement of the kidney vasculature with each nephron is crucial for the regulation of renal blood flow, GFR, urine concentration, and other specialized kidney functions. Thus, the proper and timely assembly of kidney vessels with their respective nephrons is a crucial morphogene...

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...

Patients with Chronic Kidney Disease undergo kidney replacement therapy, one of which is hemodialysis. In patients end-stage CKD, the physiological functions kidneys are reduced so that no longer able to regulate urine output. The response changes in fluid and sodium intake not functioning as it should. Excess between two hemodialysis therapies indicated by an increase body weight known Interdi...