Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...

Significant inhibition of Aurora B was achieved by the synthesis simplified fragments benzosceptrins and oroidin belonging to marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation kinase enabled discovery a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into potent CJ2-150 (37). Here we present new inhibitors...

Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deac...

objective: signaling pathways such as extracellular regulated kinase/mitogen activated protein kinase (erk/mapk) have increased activity in leukemia. ribosomal 6 kinase (rsk4) is a factor downstream of the mapk/erk pathway and an important tumor suppressor which inhibits erk trafficking. decrease in rsk4 expression has been reported in some malignancies, which leads to an increase in growth and...

Antiproliferative protein (APP) isolated from conditioned media of two androgen-independent prostatic carcinoma cell lines, PC3 and Du-145 was shown to inhibit selectively cell proliferation of androgen-dependent prostate cancer cell line LNCaP in a dose dependent manner. This protein was further purified with HPLC using hydrophobic interaction column (phenyl 5PW) and was used to study the modu...

Although ginsenoside Rg3 has been shown to exert anticancer effects on a variety of malignancies, the and molecular mechanisms oesophageal cancer remain unclear. Therefore, these factors must be explored. Here, we analyzed effect cell proliferation migration, as well its apoptosis. Furthermore, detected downstream pathways that could act on. The results showed significantly inhibited migration ...