Statins; a class of routinely prescribed cholesterol-lowering drugs; inhibit 3-hydroxy-3-methylglutaryl-coenzymeA reductase (HMGCR) and strongly induce endothelial thrombomodulin (TM); which is known to have anti-inflammatory; anti-coagulation; anti-oxidant; and radioprotective properties. However; high-dose toxicity limits the clinical use of statins. The vitamin E family member gamma-tocotrie...

T he vascular endothelium, the major interface of the vessel wall between blood and all tissues, must constantly adapt to fluctuations in environmental cues. Cellular metabolism is one mechanism that may contribute to rapid dynamic changes in cell phenotype. For example, glycolysis, one of the major forms of cellular metabolism that converts glucose to pyruvate, is required for immune cell acti...

Objective(s): Liver ischemia-reperfusion injuries (I/RI) are typically the main causes of liver dysfunction after various types of liver surgery especially liver transplantation. Radical components are the major causes of such direct injuries. We aimed to determine the beneficial effects of silibinin, a potent radical scavenger on liver I/RI.Materials...

T he health of the vascular endothelium is critical for normal vascular physiologic function, and dysfunction of the endothelium can lead to development of vascular disease, such as atherosclerosis and thrombosis. Endothelial cells (ECs) integrate hemodynamic and biochemical signals to regulate principal vascular functions, including vasoreactivity, permeability, immune cell homing, and thrombo...