In soccer knockout ties which are played in a two-legged format the team having the return match at home is usually seen as advantaged. For checking this common belief, we analyzed matches of the UEFA Champions League knockout phase since 1995. It is shown that the observed differences in frequencies of winning between teams first playing away and those which are first playing at home can be co...

Shuying Zhang Faculty Mentor: Yan Zeng Department of Pharmacology Fall 2012 Foremost, I would like to express my sincere gratitude to my advisor Prof. Yan Zeng for the continuous support of my study and growing, for his patience, motivation, enthusiasm, and immense knowledge. His guidance helped me in all the time of research and writing of this report. I could not have imagined having a better...

In GABA A b 3 knockout mice (b~@~ 3 ), inhibitory synapses between thalamic reticular (RE) neurons are selectively impaired. Consequently, oscillations in thalamic slices from b~@~ 3 mice last longer and are more synchronized than those from wild-type mice (Huntsman et al., Science 283 (1999) 541). We used computational models to study mechanisms by which intra-RE inhibition abbreviates and des...

LDL receptor-related protein 5 (LRP5) plays multiple roles, including embryonic development and bone accrual development. Recently, we demonstrated that LRP5 is also required for normal cholesterol metabolism and glucose-induced insulin secretion. To further define the role of LRP5 in the lipoprotein metabolism, we compared plasma lipoproteins in mice lacking LRP5, apolipoprotein E (apoE), or b...