Nine pyrrole-containing compounds were designed introducing reasonable structural novelties within the framework of the architecture of confirmed tuberculostatics. The new products were synthesized via adopted Paal-Knorr cyclization by condensation of three 1,4-dicarbonyl compounds with a set of substituted anilines, acting as primary amines. Preliminary in vitro tests have already registered e...

The ionic liquid 1-butyl-3-methyl-imidazolium hydrogen sulfate, [bmim]HSO4, was used as a catalyst and reaction medium for the pyrrole synthesis, and a wide range of aliphatic, aromatic, heteroaromatic and carboxylic 1,4-diketones easily underwent condensations with aniline and ethylenediamine to form polysubstituted pyrroles. Sequential decarboxylation/Paal-Knorr pyrrole condensation was obser...

Considerable amount of research has been carried out in the field of pyrazolone derivatives due to their diverse biological, pharmacological and chemical properties. The need was felt to synthesize certain 3-methyl-5-pyrazolone derivatives with potent analgesic and anti-inflammatory activity and with lesser side effects as it had been proved of late that the beneficial effects of pyrazolones ou...

A short and robust approach for the synthesis of 2-(hetero)aryl substituted thieno[2,3-b]indoles from easily available 1-alkylisatins and acetylated (hetero)arenes has been advanced. The two-step procedure includes the "aldol-crotonic" type of condensation of the starting materials, followed by treatment of the intermediate 3-(2-oxo-2-(hetero)arylethylidene)indolin-2-ones with Lawesson's reagen...

S• Knorr S, Brouwer B, and Garland SJ. Validity of the Community Balance andMobility Scale in Community-Dwelling Individuals after Stroke.• Knorr S, Ivanova TI, Doherty TJ, and Garland SJ. The Origins of Fatigue Post-stroke. Appl. Physiol. Nutr. Metab. 34 (Suppl. 1): S50, 2009.• Knorr S and Cafarelli E. Time course of central fatigue transferability in the lowerlimb. Med...

The 3-glucosides of nonamidated lithocholic, chenodeoxycholic, ursodeoxycholic, deoxycholic, and cholic acids, and their double conjugate forms with glycine and taurine were synthesized. The key reactions used were 1) beta-D- glucosidation at C-3 by the Koenigs-Knorr condensation reaction of 3 alpha-hydroxylated bile acid methyl (or p-nitrophenyl) esters with 1 alpha-bromo-1-deoxy-2, 3, 4, 6-te...

THE 4 ORIGINAL PAPERS ARE 1. Hasselbalch BJ, Knorr U, Kessing LV. Cognitive impairment in the remitted state of unipolar depressive disorder: a systematic review. J Affect Disord 2010 Dec;134(1-3):20-31. 2. Hasselbalch BJ, Knorr U, Hasselbalch SG, Gade A, Kessing LV. The cumulative load of depressive illness is associated with cognitive function in the remitted state of unipolar depressive diso...

1 Process Control Research Group, Systems and Control Laboratory, Computer and Automation Research Institute, Hungarian Academy of Sciences, H-1518 Budapest, P.O.Box 63., HUNGARY 2 Dept. of Computer Science, Pannon University, H-8200 Veszprém, Egyetem u. 10., HUNGARY 3 Knorr-Bremse Research and Development Ltd., H-1119 Major u. 69, Budapest, HUNGARY e-mail: [email protected], Piroska.Ailer...