BACKGROUND Concern has been raised that high levels of ascorbic acid consumption may lead to potential adverse effects, such as vitamin B12 deficiency, iron overload, and kidney stones. OBJECTIVE To examine the relation of serum ascorbic acid level, which reflects intake, to serum vitamin B12 level, serum ferritin level, and kidney stones. METHODS We analyzed data collected on a random samp...

Colon cancer patients with mutant KRAS are resistant to cetuximab, an antibody directed against the epidermal growth factor receptor, which is an effective clinical therapy for patients with wild-type KRAS. Numerous combinatorial therapies have been tested to overcome the resistance to cetuximab. However, no combinations have been found that can be used as effective therapeutic strategies. In t...

In our present study, different doses of allicin and L-ascorbic acid were tested against the genotoxic damage induced by chlormadinone acetate (CMA; 40 microM) using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as the parameters. Treatment with allicin and L-ascorbic acid resulted in reduction of CAs and SCEs. The results suggested a protective role of allicin and L-ascor...

Utilization of genistein as a natural inhibitor was studied alone and in combination with conventional treatments on melanosis and microbial quality of fresh L. vannamei during 10 days ice storage. Treatments were as followed: A (dipping samples in distilled water), B (dipping in 1.25 % sodium metabisulphite solution), C (dipping in 0.01 % genistein + 2% glycerol solution), D (dipping in 0.1 % ...

L-ascorbic acid is found in equilibrium with its oxidative degradation product, L-dehydroascorbic acid, which is used in the body in the same way as ascorbic acid. L-dehydroascorbic acid has its maximum stability at room temperature at pH 2-3 and it will at pH values above 7 degrade irreversibly during formation of 2,3-diketogulonic acid which shows no vitamin C activity. Finally, at high pH va...

Ascorbic acid is catabolized to yield oxalate from carbon atoms 1 and 2 (1, 2) and carbon dioxide from carbon atom 1 in man as well as in other species (3-5). It has also been shown that n-glucuronolactone is converted to ascorbic acid in the human 63. The present studies were designed to determine the n-ascorbic acid metabolic pool size and turnover rate, the fraction of the urinary oxalate wh...

BACKGROUND Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and reverse causation. OBJECTIVES We assessed the relation between L-ascorbic acid and 10 cardiometabolic traits by using a single nucleotide polymorphism in the solute carrier family 23 member 1 (SLC23...

Background: Liposomes constitute a promising drug delivery vehicle, and are believed to improve drugs’ effectiveness. This study was aimed to compare antihypertensive and vascular modifying activities of liposomal and non-liposomal forms of ascorbic acid. Methods: Forty-nine male Sprague-Dawley rats were randomly divided into seven groups (n=7): A sham vehicle-receiving (Sham-veh), hypert...