Sir: It was shown previously that both L[guanidino-14C] arginine and L-[ureido-14C] citrulline are efficient mitomycin (I) precursors which specifically label the carbamoyl-group of these antibiotics1,3. Sodium-[14C] carbonates', [14C] urea1) and potassium-[14C] cyanate3' are inefficient precursors and this is presumably due to either inefficient uptake or loss of the label as carbon dioxide fr...

Background: Watermelon is a rich natural source of l-citrulline. This non-essential amino acid increases exercise performance. Objective: Evaluate the effect of Fashion watermelon juice enriched in l-citrulline (CWJ) (3.45 g per 500 mL) in physical performance and biochemical markers after a half-marathon race. Design: A randomised, double blind, crossover design where 2 h after drinking 500 mL...

This study was designed to assess the production of nitric oxide (NO) by neutrophils in bronchial asthma. Thirty asthmatic patients (ten each of mild, moderate and severe asthma) and ten healthy controls were included in the study. Neutrophils from peripheral venous blood were stimulated with latex, and production of nitrite (an NO metabolise) and L-citrulline (a co-product of NO) was studied. ...

BACKGROUND: Carotid atherosclerosis (CA) and lower extremity peripheral artery disease (PAD) is a common potentially life-threatening comorbidity in diabetes. AIM: to determine risk factors biomarkers of the association CA PAD patients with type 2 MATERIALS AND METHODS : A single-center cross-sectional comparative study was carried out. Three hundred ninety one diabetes were included. Duplex ul...

During malolactic fermentation (MLF) in grape must and wine, heterofermentative lactic acid bacteria may degrade arginine, leading to the formation of ammonia and citrulline, among other substances. This is of concern because ammonia increases the pH and thus the risk of growth by spoilage bacteria, and citrulline is a precursor to the formation of carcinogenic ethyl carbamate (EC). Arginine me...

The amino acid arginine is the sole precursor for nitric oxide (NO) synthesis. We recently demonstrated that an acute reduction of circulating arginine does not compromise basal or LPS-inducible NO production in mice. In the present study, we investigated the importance of citrulline availability in ornithine transcarbamoylase-deficient spf(ash) (OTCD) mice on NO production, using stable isotop...

Arginine metabolism by wine lactic acid bacteria (LAB) may lead to wine quality degradation. While arginine is essential for growth of the wine relevant LAB Oenococcus oeni, it remains unclear whether it also stimulates its growth. This study evaluated the effect of arginine and citrulline, the partially metabolized intermediate of the arginine deiminase pathway, on the growth of two commercial...

Various studies have shown a role for citrulline as a gut mass biomarker in patients with short bowel syndrome. Our hypothesis is that plasma citrulline is both a gastrointestinal (GI) function and a gut mass marker. Our objective was to validate previous observations, by prospectively analyzing plasma citrulline concentrations in patients with GI disease with or without bowel resection, compar...

BackgroundLevels of plasma citrulline (citrulline-P), a biomarker for enterocyte function, might be useful the monitoring course necrotizing enterocolitis (NEC). Our aim was to evaluate whether citrulline-P levels during first 48 h (h) after NEC onset were associated with need surgery, survival, and intestinal recovery.MethodsIn preterm infants (Bell's stage ≥2) we measured onset. Categorizing ...

Background Citrulline has been described as a marker of intestinal function or absorption but evidence varies according to clinical settings. Objective The objective of this article is to examine the evidence of plasma citrulline as a marker of intestinal function and absorption in various clinical settings. Methods Studies were examined for p values, means and standard deviations, correlat...