Control of the protozoan parasite Leishmania major is dependent on establishing a robust T cell response. An early event in the development of an effective T cell response is the expansion (or hypertrophy) of the lymph node draining the site of infection, although the mechanisms involved in this response are not completely understood. In this study, we show that lymph node hypertrophy following...

background: cutaneous leishmaniasis is one of the most important parasitic diseases in humans. in this disease, one of the responsible organisms is leishmania major, which is transmitted by sandfly vector. there are specific differences in biochemical profiles and metabolite pathways in logarithmic and stationary phases of leishmania parasites. in the present study, 1h nmr spectroscopy was used...

Zoonotic cutaneous leishmaniasis caused by Leishmania major is a most common type of vector-borne disease in Iran. The pentavalent antimonial drugs have been used in the treatment of cutaneous leishmaniasis for a long time, but drug resistance and some of serious side effects have been reported. Thus, discovery and development of new therapeutic candidates are needed. The CM11 peptide ...

In this work we describe an unusual enzyme from Leishmania major (Arabinokinase/Pyrophosphorylase) that catalyzes the synthesis of GDP-D-arabinopyranose (GDP-D-Arap) via a D-arabinose-1-phosphate intermediate in the presence of ATP and GTP. Our data indicate GDP-D-Arap transport in vivo by the LPG2 multispecific nucleotide sugar transporter into the Leishmania Golgi apparatus, in which it can b...

BACKGROUND Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate the familiality of AAO and episode frequency in MDD and to assess the propor...

Introduction: Paper and paperboard industry wastewater has potentially damaging effects on the ecosystem of the receiving environments due to the presence of toxic compounds. As a result, the treatment of such wastewater is necessary prior to discharge into the environment. In this study, the potential of Plantago major L. seed extract as a natural coagulant in treating paper and paperboar...

The potential of Leishmania major culture-derived soluble exogenous antigens (SEAgs) to induce a protective response in susceptible BALB/c mice challenged with L. major promastigotes was investigated. Groups of BALB/c mice were immunized with L. major SEAgs alone, L. major SEAgs coadministered with either alum (aluminum hydroxide gel) or recombinant murine interleukin-12 (rmIL-12), L. major SEA...

BACKGROUND Infection with Leishmania results in a broad spectrum of pathologies where L. infantum and L. donovani cause fatal visceral leishmaniasis and L. major causes destructive cutaneous lesions. The identification and characterization of Leishmania virulence genes may define the genetic basis for these different pathologies. METHODS AND FINDINGS Comparison of the recently completed L. ma...

abortion can lead to major economic losses. l. monocytogenes and l. ivanovii can cause infertility and abortion. considering the importance of what mentioned, present study was conducted to detection of l. monocytogenes and  l. ivanovii in bovine abortion from shahrekord, iran. vaginal discharge from 36 aborted cows were investigated to  detection of l. monocytogenes and l. ivanovii. the sample...