Leishmaniasis is a worldwide disease still treated with expensive compounds that present severe side effects, and are frequently ineffective emphasizing the importance to search effective compounds against this disease. Miltefosine drug (HePC) that used as antitumor agent has been used against Leishmania tropica in two forms promastigote and axenic amastigote in vitro conditions. Different conc...

Black rats (Rattus rattus) receiving Leishmania tropica injected intradermally into the ear were studied for the persistence of parasites and infectivity to natural sand fly vector. The mammalian host, the parasite, and the vector all originated from the endemic focus of Urfa, Turkey. Rats did not develop lesions or any apparent signs of disease, although at the site of inoculation they harbour...

An in vitro investigation was carried out to assess how the lipopeptide biosurfactant (LPB) produced by Acinetobacter junii B6 affects Leishmania tropica infection and associated cytokine gene expression macrophages infected with L. tropica. Glucantime® (meglumine antimoniate, MA) LPB were investigated for their leishmanicidal effect, alone combination (LPB + MA), using a colorimetric test macr...

background: cutaneous and visceral leishmaniases are present in fars province in the south of iran. the current study aimed to evaluate the inter- and intragenic diversities of leishmania species isolated from patients with leishmaniasis in fars province, using pcr-based analyses and dna sequencing of  the n-acetylglucosamine-1-phosphate transferase ( nagt ) gene. methods: clinical samples were...

background: leishmaniasis is a common parasitic disease world wide. leishmania tropica and l. major are two common cause of cutaneous leishmaniasis in iran. the aim of this study was determination of the cause of cutaneous leishmaniasis in shush city, khouzestan province, southwest iran methods: one hundred samples were collected from patients at the age of 1-80 year with documented cutaneous l...

Background: Characterization of Leishmania parasites is necessary for epidemiological objectives such as documenting the distribution of predominant species and designing appropriate control measures. In this study, we aimed to identify Leishmania species isolated from cutaneous leishmaniasis (CL) patients, using RAPD-PCR method. Methods: This descriptive, cross-sectional study was designed aga...

BACKGROUND Three major forms of human disease, cutaneous leishmaniasis, visceral leishmaniasis and mucocutaneous leishmaniasis, are caused by several leishmanial species whose geographic distribution frequently overlaps. These Leishmania species have diverse reservoir hosts, sand fly vectors and transmission patterns. In the Old World, the main parasite species responsible for leishmaniasis are...

BACKGROUND Research in our laboratory has previously shown that immune-mediated transmission blocking may be applied to Leishmania infections and that the LPG molecule and anti-LPG monoclonal antibodies was found to be an excellent candidate against L. major infections. OBJECTIVE To test the effect of monoclonal antibodies (MABs) raised against different species of Leishmania for their abilit...

Despite the great efforts by health authorities in Kingdom of Saudi Arabia (KSA), Cutaneous leishmaniasis (CL) continues to be a major public health problem in the country. Many risk factors make KSA prone to outbreaks and epidemics; among these, rapid urbanization and the huge population movement are the most important. The disease is endemic in many parts of KSA, with the majority of cases co...

background : the goal of this study was to know the identity of leishmania species responsible of cutaneous leishmaniasis (cl) in fars province, southern iran. methods : five counties of shiraz, firouz abad, ghir-karzin, farashband and larestan were pros-pected. forty-four patients exhibiting cutaneous lesions were selected. samples collected on skin le-sions were examined both microscopically ...