Protozoan parasites [1]: 1) Leishmania major; 2) L. tropica; 3) L. infantum (very rare) WHO case definition Suspected case A person showing clinical signs (skin lesions). A papule appears, which may enlarge to become an indolent ulcerated nodule or plaque. The sore remains in this stage for a variable time before self healing and typically leaves a depressed scar. Other atypical forms may occur...

L eishmaniasis currently threatens 350 million people in 88 countries around the world. Ninety per cent of cutaneous leishmaniasis (CL) cases occur in Afghanistan, Brazil, Iran, Peru, Saudi Arabia, and Syria. An epidemic of cutaneous leishmaniasis is ongoing in Kabul, Afghanistan with an estimated 200 000 cases. Lesions can be very disfiguring, particularly on the face, which may have long term...

leishmaniasis is caused by parasitic protozoa of the genus leishmania. cutaneous leishmaniasis (cl) is a complex disease with wide spectrum of clinical manifestations. in order to identify leishmania species causing cl in isfahan by a definite molecular technique (pcr method), this study was undertaken over 2010- 2011. 124 patients with suspicious lesion of leishmaniasis and positive direct sme...

Protozoan parasites [1]: 1) Leishmania major; 2) L. tropica; 3) L. infantum (very rare) WHO case definition Suspected case A person showing clinical signs (skin lesions). A papule appears, which may enlarge to become an indolent ulcerated nodule or plaque. The sore remains in this stage for a variable time before self healing and typically leaves a depressed scar. Other atypical forms may occur...

BACKGROUND Leishmania major and an uncharacterized species have been reported from human patients in a cutaneous leishmaniasis (CL) outbreak area in Ghana. Reports from the area indicate the presence of anthropophilic Sergentomyia species that were found with Leishmania DNA. METHODOLOGY/PRINCIPAL FINDINGS In this study, we analyzed the Leishmania DNA positive sand fly pools by PCR-RFLP and IT...

Protozoan parasites [1]: 1) Leishmania major; 2) L. tropica; 3) L. infantum (very rare) WHO case definition Suspected case A person showing clinical signs (skin lesions). A papule appears, which may enlarge to become an indolent ulcerated nodule or plaque. The sore remains in this stage for a variable time before self healing and typically leaves a depressed scar. Other atypical forms may occur...

This study aimed to evaluate the in vitro and in vivo leishmanicidal activity of an endemic Turkish plant and compare its efficacy with a reference drug. In addition to the in vitro activities of the ethanol, acidified and alkaloid extracts and furoquinoline alkaloids skimmianine and gamma-fagarine, in vivo antileishmanial activitiy of the acidified extract of Haplophyllum myrtifolium Boiss. (R...

Despite the broad distribution of leishmaniasis among Iranians and animals across the country, little is known about the genetic characteristics of the causative agents. Applying both HSP70 PCR-RFLP and sequence analyses, this study aimed to evaluate the genetic diversity and phylogenetic relationships among Leishmania spp. isolated from Iranian endemic foci and available reference strains. A t...

BACKGROUND Leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. The present study was aimed to investigate antileishmanial effects of various extracts of Berberis vulgaris also its active compoenent, berberine against Leishmania tropica and L. infantum species on in vitro experiments. METHODS In this study in vitro antileishmanial activity...

BACKGROUND Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are unresponsive to meglumine antimoniate (Glucantime), the first line of treatment in Iran. This study was designed to determine whether the clinical responses (healing, or non-healing) were correlated with the susceptibility of Leishmania parasites to Glucantime. MET...