recently, it has been shown that a number of hydroxypyridinones such as 1,2-dimethyl-3-hydroxypyridin-4-one (l1) are useful for the treatment of iron overload in place of desferrioxamine in thalassaemic patients. in this study, the intestinal absorption (i.a.) of l1 and one of its analogues namely 2-methy-3-hydroxypyridin-4-one (l2), which possesses a higher partition coefficient (kpart) than l...

We investigated the interplay between surface trafficking and binding dynamics of the immunoglobulin cell adhesion molecule L1 at neuronal growth cones. Primary neurons were transfected with L1 constructs bearing thrombin-cleavable green fluorescent protein (GFP), allowing visualization of newly exocytosed L1 or labeling of membrane L1 molecules by Quantum dots. Intracellular L1-GFP vesicles sh...

Background Urothelial carcinoma ranks the ninth among malignant cancers. We conducted this study to identify which patients could benefit more from the treatment of programmed death-1 (PD-1)/programmed death-ligand1 (PD-L1) inhibitors. Materials and Methods We performed literature searches, combined data from qualified literature and performed comparative analyses on the effectiveness of anti...

A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at normal levels. In vitro experiments showed that L1-L1 homophilic binding was lost, along with L1-alpha5beta1 integrin binding. However, L1-neurocan and L1-neuropilin binding were preserved and sema3a responses were in...

L1 is a cell adhesion molecule of the immunoglobulin (Ig) superfamily, critical for central nervous system development, and involved in several neuronal biological events. It is a type I membrane glycoprotein. The L1 ectodomain, composed of six Ig-like and five fibronectin (Fn) type-III domains, is involved in homophilic binding. Here, co-immunoprecipitation studies between recombinant truncate...

PC L1 Misses L2 Misses Number of EAs PC L1 Misses L2 Misses Number of EAs PC L1 Misses L2 Misses Number of EAs PC L1 Misses L2 Misses Number of EAs PC L1 Misses L2 Misses Number of EAs PC L1 Misses L2 Misses Number of EAs PC L1 Misses L2 Misses Number of EAs PC L1 Misses L2 Misses Number of EAs 1 463592

EA L1 Misses L2 Misses Number of PCs EA L1 Misses L2 Misses Number of PCs EA L1 Misses L2 Misses Number of PCs EA L1 Misses L2 Misses Number of PCs EA L1 Misses L2 Misses Number of PCs EA L1 Misses L2 Misses Number of PCs EA L1 Misses L2 Misses Number of PCs EA L1 Misses L2 Misses Number of PCs 1 268855128 527448 9598 11925 268855128 522745 5 11721 268855128 523571

L1-cell adhesion molecule (L1-CAM) belongs to a functionally conserved group of neural cell adhesion molecules that are implicated in many aspects of nervous system development. In many neuronal cells the adhesive function of L1-type CAMs induces cellular signaling processes that involves the activation of neuronal tyrosine protein kinases and among other functions regulates axonal growth and g...

The L1 adhesion molecule plays an important role in axon guidance and cell migration in the nervous system. L1 is also expressed by many human carcinomas. In addition to cell surface expression, the L1 ectodomain can be released by a metalloproteinase, but the biological function of this process is unknown. Here we demonstrate that membrane-proximal cleavage of L1 can be detected in tumors and ...

Antibodies targeting the PD-1/PD-L1 immune checkpoint lead to tumor regression and improved survival in several cancers. PD-L1 expression in tumors may be predictive of response to checkpoint blockade therapy. Because tissue samples might not always be available to guide therapy, we developed and evaluated a humanized antibody for non-invasive imaging of PD-L1 expression in tumors. Radiolabeled...