Structure-activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole ...

This study undertook to discern the effect the production strategy dimension had on technological growth in a developing country. It utilized robust indicators that measured the penetration of advanced manufacturing technologies in the Ugandan machine tool driven industry. Poor or the lack thereof of comprehensive production strategies had a profound effect on the development of this industry. ...

Pseudomonas aeruginosa, an important nosocomial pathogen is difÞ cult to treat because of high antimicrobial resistance.[1] The common form of resistance is mediated by lack of drug penetration and / or carbapenem hydrolyzing ß-lactamases.[2] Detection of metallo ß lactamase (MBL)producing P. aeruginosa is crucial for the optimal treatment of patients. The present study was undertaken to study ...

Ultra Wide Band (UWB) signalling is expected to play an important role in the future of communications systems. UWB uses extremely wide transmission bandwidths (in excess of 3 GHz), which results in desirable potentials such as accurate position location and ranging, lack of significant fading, high multiple access capability, secure communications, and possible easier material penetration. The...

Conventional drilling of rock, in most mining applications, uses the mechanical impact of a metal tool to create the advancing hole. This technique, which has gradually increased in power and thus penetration rate has, however, certain inherent disadvantages. These range from the overall weight of the equipment which must be located at the free face of the hole to the maintenance of alignment o...

In this study, we explore the global effect of the Internet on democracy over the period of 1992 to 2002 by observing the relationships between measures related to democracy and Internet prevalence. Our findings suggest that while Internet usage was not a very powerful predictor of democracy when examining full panel data from 1992 to 2002, it was a stronger predictor when we study data from ju...

The need for a drying stress indicator has previously been stated with some research in the past to this means. Given the recent successes in achieving this goal through monitoring shrinkage, the refinement and further understanding of the process was needed, specifically, the influence that penetration of the mount-foot had on the shrinkage data. Four different LVDTmounts were investigated in ...

Also psychological factors should play a crucial role to arouse this dysfunction. The problems such as avoidance, fear of penetration, anxiety, relationship problems, chronic frustration, disappointment and depression, previous child sexual abuse could be experienced by patients as painful spasmodic reflex. In addition, poor sexual self-esteem, lack of interest, and general inability to find pl...

The investigation of fatigue strength needs an accurate solution and reliable values of the stress intensity factor (SIF). In this study, SIF of load-carrying cruciform welded joints has been evaluated using finite element method (FEM), and compared with the available solutions from literature. Load-carrying cruciform welded joints with isosceles triangles and non-isosceles triangle fillet weld...