The spindle assembly checkpoint (SAC) functions as a surveillance mechanism to detect chromosome misalignment and to delay anaphase until the errors are corrected. The SAC is thought to control mitosis and meiosis, including meiosis in mammalian eggs. However, it remains unknown if meiosis in the eggs of nonmammalian vertebrate species is also regulated by SAC. Using a novel karyotyping techniq...

north Darfur is not receiving health care, and 370 000 people across Darfur did not receive monthly rations in July. One of the most important lessons is that without durable peace, the health gains can easily be lost. Health indicators must be used as an advocacy tool in the political process. The international community must critically examine its efforts in order to achieve sustainable resul...

Rad23 is an adaptor protein that binds to both ubiquitinated substrates and to the proteasome. Despite its association with the proteasome, Rad23 escapes degradation. Here we show that Rad23 remains stable because it lacks an effective initiation region at which the proteasome can engage the protein and unfold it. Rad23 contains several internal, unstructured loops, but these are too short to a...

We want to correct some statements that we published in an earlier volume of IOVS. We described microglia and macrophages in the normal rat retina and the response of these cells during the endotoxin-induced uveitis model (EIU). Retinal wholemounts from normal rats and at various time points after endotoxin injection were stained with the monoclonal antibodies ED1 and ED2. We reported the stain...