The objective of this study was to determine the influence of pleural and ascitic fluid on the pharmacokinetics of the antitumor camptothecin derivative topotecan. Four patients with histological proof of malignant solid tumor received topotecan (0.45 or 1.5 mg/m2) p.o. on several occasions in both the presence and absence of third space volumes. Serial plasma and pleural or ascitic fluid sampl...

epic poetry is a sort of ancient literature which exists in most of the world's literatures such as roman, greek, indian and iranian; but arabic literature has not used this type of literature. major reasons for this are as follows: 1. lack of nationalistic sense 2. arabic poetry is mostly based on vocality 3. there haven't been real long term wars between arabs 4. arabic poetry has h...