BACKGROUND Decrease in lacrimal gland secretory function is related to age-induced dry eye disease. Lactoferrin, the main glycoprotein component of tears, has multiple functions, including anti-inflammatory effects and the promotion of cell growth. We investigated how oral administration of lactoferrin affects age-related lacrimal dysfunction. METHODS AND FINDINGS Twelve-month-old male C57BL/...

Lactoferrin is an iron-binding protein present in external secretions and the secondary granules of neutrophils Its function is unknown, although immunomodulatory, antiinfective and nutritional roles have been proposed 11 I. Recently autoantibodies to lactofemn have been found as a component of anti-neutrophil cytoplasmic antibodies (ANCA) in patients with various autoimmune diseases 121. Why l...

The innate defense system of the female mucosal genital tract involves a close and complex interaction among the healthy vaginal microbiota, different cells, and various proteins that protect the host from pathogens. Vaginal lactobacilli and lactoferrin represent two essential actors in the vaginal environment. Lactobacilli represent the dominant bacterial species able to prevent facultative an...

BALB/c mice were intravenously injected with lipopolysaccharide (LPS) (0.05 microg/g of body weight) 7 days after being primed with zymosan. Recombinant human lactoferrin (250 microg/g of body weight), intravenously administered 1 day before the injection of LPS, significantly lessened the severity of hepatitis, as assessed by levels of serum alanine transaminase compared to those seen when cas...

Corresponding Author: Fatemeh Moradian Assistant professor of Biochemistry, Basic Sciences Group, Sari Agricultural Sciences and Natural Resources University, Sari, Mazandaran, Iran, P.O.B. 578. Telefax:+98-11-33687655 E-mail: [email protected] & [email protected] Abstract Background: Lactoferrin is a glycoprotein with a molecular weight of 80 kDa, as a member of the transferring family. In...

Human umbilical vein endothelial cells were cultured in supernatants of peripheral blood monocytes that had been cultured for 3 days with and without lactoferrin. Colonystimulating activity (CSA) was measured in supernatants of the endothelial cell cultures and appropriate control cultures using normal. T-Iymphocyte-depleted. phagocytedepleted, low-density bone marrow cells in colony growth (CF...

Lactoferrin (LF) is an 80 kD iron-binding glycoprotein that is most highly produced in human and bovine milk and is also widely distributed in mammals. Researches of more than 70 years on lactoferrin prove that the molecule, as a nutritional molecule for mammals, possesses several physiological roles, including maintaining iron absorption, anti-microbial activity and immune modulation. Recent s...

Human airway epithelial cells can increase expression of both lactoferrin and ferritin after exposure to catalytically active metal. These proteins transport and store metal, with coordination sites fully complexed, and therefore can diminish the oxidative stress. The intracellular transport of lactoferrin results in a transfer of complexed metal to ferritin, where it is stored in a less reacti...

Lactoferrin binds to rat hepatic lectin 1 (RHL1), the major subunit of the asialoglycoprotein (ASGP) receptor, with high affinity, by a galactose-independent mechanism. To better understand the molecular basis of this novel interaction, we compared the binding of lactoferrin and asialo-orosomucoid (ASOR) to isolated rat hepatocytes and to purified ASGP receptors as a function of pH, Ca(2+) and ...

The comparison of measurements of fibronectin and lactoferrin in ejaculates from vasectomized men, subjects with functional deficiency or aplasia of the seminal vesicles, and reference subjects provided evidence that both the fibronectin and the lactoferrin in human seminal fluid originate from the seminal vesicles and the ampullae. The fibronectin is incorporated in the framework of the semina...