INTRODUCTION Inflammation in dental pulp cells (DPCs) initiated by Lipopolysaccharide (LPS) results in dental pulp necrosis. So far, whether there is a common system regulating inflammation response and tissue regeneration remains unknown. miR-146a is closely related to inflammation. Basic fibroblast growth factor (bFGF) is an important regulator for differentiation. METHODS To explore the ef...

Spinal cord injury (SCI) results in neuronal and glial death and the loss of axons at the injury site. Inflammation after SCI leads to the inhibition of tissue regeneration and reduced neuronal survival. In addition, the loss of axons after SCI results in functional loss below the site of injury accompanied by neuronal cell body's damage. Consequently, reducing inflammation and promoting axonal...

Marco Romanelli is Consultant Dermatologist, Department of Dermatology, University of Pisa, Pisa, Italy Amelogenin is an extracellular matrix protein with biological activity in the regeneration of the periodontium and repair of the skin. Recent published studies have highlighted the use of Xelma® (Mölnlycke Health Care AB, Göteborg, Sweden) in the treatment of hard-to-heal wounds, such as veno...

Hyaluronic acid (HA) is a natural-non sulphated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. The use of HA in the treatment of inflammatory process is established in medical areas such as orthopedics, dermatology and ophthalmology. In the field of denti...

Inflammatory skin diseases are difficult to treat because of a lack of available treatment options for severe disease. However, recent advances have shown that vagus nerve stimulation can be used to decrease inflammation and reduce disease severity in rheumatoid arthritis and inflammatory bowel disease. Changes in cytokine profiles observed in these studies are similar to those seen with use of...

Background: Psoriasis vulgaris is a recurrent chronic skin disorder signed by hyperproliferation and epidermal inflammation. One of the etiology psoriasis genetic factors related to polymorphism as disease susceptibility markers. This study was aimed analyze correlation TNF-α gene promoter region with vulgaris. Methods: An analytical observational cross-sectional design identify TNF-region po...

The renin-angiotensin-aldosterone system (RAAS) has a noteworthy part in triggering, and inflammation is maintained by its physiological agents. A crucial mechanism for the initiation headway of CVD, including Hypertension atherosclerosis, inflammation. In addition to primary function controlling blood pressure contribution Hypertension, RAAS pro-inflammatory profibrotic cellular molecular effe...

Microbial transformation of lapachol, a naturally occurring naphthoquinone, was carried out by Curvularia lunata (NRRL 2178). The fungus brings about oxidative cyclization of the substrate to dehydro-alpha-lapachone, which was isolated and characterized by nuclear magnetic resonance and mass spectral analyses; its structure was verified by chemical synthesis. The metabolite is a naturally occur...

308nm xenon-chloride excimer laser, a novel mode of phototherapy, is an ultraviolet b radiation system consisting of a noble gas and halide. the aim of this systematic review was to investigate the literature and summarize all the experiments, clinical trials and case reports on 308-nm excimer laser in dermatological disorders. 308-nm excimer laser has currently a verified efficacy in treating ...

The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the original architecture by proliferation and remodeling of the remaining cells within a week. In contrast, chronic liver inflammation due to various etiologies, e.g., virus infection and me...