1 Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, P. R. China. 2 College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, P. R. China. 3 Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 609-735, Korea. 4 De...

Editor’s note: Each month, this department features a discussion of an unusual diagnosis in genetics, radiology, or dermatology. A description and images are presented, followed by the diagnosis and an explanation of how the diagnosis was determined. As always, your comments are welcome via e-mail at [email protected]. Josephine L. Reece, MD, is Internal Medicine and Pediatric Resident, West ...

The immune responses of humans and animals to insults (i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged pro-inflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenc...

Recent studies have suggested that selective targeting of overexpressed enzymes in cancer cells by small molecules that induce the formation of reactive oxygen species (ROS) could be a viable approach in cancer therapy. One such example is the inactivation of ubiquitin specific protease-2 (USP2)-an emerging drug target to combat prostate cancer-by β-lapachone, which has been identified to invol...

abstract background: chronic urticaria (cu) is a common dermatological disease that induces a substantial burden on individuals’ life. also if one’s self-image changes (which usually happen in patients with dermatological diseases), it leads to anxiety or other various symptoms. we aimed to compare the psychological scales in patients with cu with non-dermatological individuals with the purpose...

Manuscript Number: CELL-METABOLISM-D-13-00308R2 Full Title: AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration Article Type: Research Article

The RAAS through its physiological effectors plays a key role in promoting and maintaining inflammation. Inflammation is an important mechanism in the development and progression of CVD such as hypertension and atherosclerosis. In addition to its main role in regulating blood pressure and its role in hypertension, RAAS has proinflammatory and profibrotic effects at cellular and molecular levels...

A 6 year-old male patient was admitted to the dermatology department with an eruption on the right arm, chest and left leg. No clinical symptoms such as pain, pruritus or previous inflammation were present. His mother reported that the lesion had developed four years ago as small-sized hyperpigmented macules which enlarged in a short period of time as band-like hyperpigmentation, and then remai...