central nervous system axons fail to regenerate after spinal cord injury (sci), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. this study evaluated the histological changes (cavitation and axon regeneration) after sci associated with (following ad...

Seborrheic Dermatitis is a common dermatological problem that affects the seborrheic areas of body. Dandruff restricted to scalp, and involves itchy, flaking skin without visible inflammation. scalp as well face, retro-auricular area, upper chest, causing flaking, scaling, inflammation pruritus, can have marked erythema. Flaking in usually white-to-yellowish, greasy. It may cause discomfort emo...

Aim of study Taheebo polyphenols (TP) are water extracts of Tabebuia spp. (Bignoniaceae), taken from the inner bark of the Tabebuia avellanedae tree, used extensively as folk medicine in Central and South America. Some anti-inflammatory drugs act by inhibiting both cyclooxygenase-2 (COX-2) and COX-1 enzymes. COX-2 syntheses prostaglandin (PG) E2, which is a species of endogenous pain-producing ...

Abstract Lagoa do São Bento is a coastal restinga wetland, remnant of paleolake, located in Maricá, RJ. The study aimed to inventory native aquatic plants, make floristic comparison with other lagoons and analyze the regeneration this community after anthropic impacts. In analysis 45 species were listed, 39 which are Angiosperms six Ferns. Aeschynomene paniculata, Hymenachne amplexicaulis, Mont...

Mesenchymal stem cell (MSC)-based transplantation is a promising therapeutic approach for bone regeneration and repair. In the realm of therapeutic bone regeneration, the defect or injured tissues are frequently inflamed with an abnormal expression of inflammatory mediators. Growing evidence suggests that proinflammatory cytokines inhibit osteogenic differentiation and bone formation. Thus, for...

Research on liver cancer prevention and treatment has mainly focused on the liver cancer cells themselves. Currently, liver cancers are no longer viewed as only collections of genetically altered cells but as aberrant organs with a plastic stroma, matrix, and vasculature. Improving the microenvironment of the liver to promote liver regeneration and repair by affecting immune function, inflammat...

The inflammation that accompanies injury and disease is a defense reaction, constituting an important part of the natural innate immune response. In any organ, inflammation is necessary for the healing process to reduce the size of a damaged or necrotic area and replace it with new tissue. When the necrotic area is replaced by new functional tissue, it is called regeneration; when it is instead...

Background: Interleukin-6 (IL-6), as a multifunctional cytokine, was involved in the inflammation microenvironment of muscle regeneration. Result: In mice lack IL-6, less macrophages recruitment and decreased myoblast proliferation impairs muscle regeneration. Conclusion: In monocytes/macrophages, activation of IL-6/STAT3 pathway is critical to macrophages migration and myoblast proliferation d...