OBJECTIVE To assess the capacity of high and low doses of the antimitotic drug mitomycin to prevent laryngeal stenosis in an animal model. METHODS A prospective, randomized, double-blind, controlled study was carried out. End-to-end anastomosis was performed in 18 rabbits after tracheal annulus resection to produce inflammation. There were 3 treatment groups: topical saline (isotonic sodium c...

OBJECTIVES To describe our management of complex glottic stenosis in tracheotomy dependent children with severe recurrent respiratory papillomatosis. METHODS Retrospective chart review at a tertiary care children's hospital. RESULTS Three children with complex glottic stenosis secondary to severe recurrent respiratory papillomatosis were treated at our institution since 2011. Two patients h...

Congenital high airway obstruction syndrome is rare fetal malformation caused by obstruction of fetal airway because of laryngeal or tracheal atresia, subglottic stenosis, laryngeal cyst or laryngeal web. This clinical condition was brought into notice first by Hedrick in the late 1900 [1]. CHAOS is usually caused by atresia or stenosis of the larynx or trachea. The true incidence of CHAOS is u...

Introduction: The techniques of partial laryngectomy are based on the compartimentalization of the larynx and their aims are to provide the oncologically radical excision and to preserve the laryngeal function. Objective: To evaluate the oncological results and the complications in patients submitted to these techniques. Methods: A consecutive series of 120 patients underwent partial laryngecto...

Objective. Infants with respiratory failure may require prolonged intubation. There is no consensus on the time of tracheotomy in neonates. Methods. We evaluated infants applied tracheotomy, time of procedure, and early complications in our neonatal intensive care unit (NICU) retrospectively from January 2012 to December 2013. Results. We identified 9 infants applied tracheotomy with gestationa...

The patient, a girl, 24 years old, was born in Jamaica, the birth weight being 74 lb. Pregnancy was normal, with the delivery at full term. There was no dyspnoea or cyanosis at birth. Stridor and attacks of 'cyanosis' started soon after birth, especially with feeds, culminating with a very severe attack at II months. A direct laryngoscopy was performed, and the larynx was 'probed'. The conditio...

Background Treatment of tracheostenosis after tracheostomy in pediatric patients is often difficult. Mucopolysaccharidosis is a lysosomal storage disease that may induce obstruction of the airways. Case Presentation A 16-year-old male patient underwent long-term follow-up after postnatal diagnosis of type II mucopolysaccharidosis. At 11 years of age, tracheostomy was performed for mucopolysac...

Accelerated hyperfractionated radiotherapy was performed as treatment for patients with T1 glottic cancer, and its utility was evaluated based on treatment outcomes and adverse effects. Fifty-eight men who had undergone radiotherapy were retrospectively reviewed. Tumor classification was Tis in 4 patients, T1a in 38, and T1b in 16. Histological examination revealed squamous cell carcinoma in 55...

BACKGROUND Lung ventilation through a thin transtracheal cannula may be attempted in patients with laryngeal stenosis or "cannot intubate, cannot ventilate" situations. It may be impossible to achieve sufficient ventilation if the lungs are spontaneously emptying only through the thin transtracheal cannula, which imposes high resistance to airflow, resulting in dangerous hyperinflation. Therefo...

PURPOSE OF REVIEW To summarize the diagnosis, pathology, and management of glottic, subglottic, and tracheal injuries secondary to endotracheal intubation in neonates. RECENT FINDINGS Published reports of intubation-related injuries include laryngeal stenosis, subglottic stenosis (SGS), tracheal rupture, subglottic cysts, and pharyngoesophageal perforation. Such injuries are multifactorial, w...