Gene essentiality in bacteria has been identified in silico, focusing on gene persistence, or experimentally, focusing on the growth of knockouts in rich media. Comparing 55 genomes of Firmicutes and Gamma-proteobacteria to identify the genes which, while persistent among genomes, do not lead to a lethal phenotype when inactivated, we show that the characteristics of persistence, conservation, ...

With an evolutionary history that spans several thousands of years, Ayurveda is one of the oldest and meticulously codifi ed systems of health care in the world. However, in modern times, the Ayurvedic community has lagged behind in the task of projecting Ayurveda as an evidence-based system with adequate research support to vouchsafe its therapeutic claims of safety and effi cacy. For this rea...

The research articles listed here cover the period 1963 to the present. They are all important articles, and they are relevant to this offering of the course.

 Abegglen, J., Christiaens, G. & Rowley, A. (2008). Nursing students' perceptions of a holistic nursing conference: Empowerment, self care, and application to practice. Journal of Holistic Nursing, 26(2), 139-146. The purpose of the study was to describe nursing students' perceptions of their experiences at the 2007 annual conference of the American Holistic Nurses Association (AHNA), and iden...

The paper provides 'rules of thumb' for writing research articles (RA) and getting them published. These were discussed during the "Scientific writing course" organized for ITC PhD students by Cressie Communication Services. Important aspects of macro and sub-structure of a paper were selected through group discussions. The substructure and functions of different sections of RAs are described. ...

It is shown that it takes several years for a mandatory policy to be institutionalized and routinized, but that once it has been the deposit of articles takes place in a remarkably short time after publication, or in some cases even before. Authors overwhelmingly deposit well before six months after publication date. The OA mantra of ‘deposit now, set open access when feasible’ is shown to be n...

Solvation plays an important role in ligand-protein association and has a strong impact on comparisons of binding energies for dissimilar molecules. When databases of such molecules are screened for complementarity to receptors of known structure, as often occurs in structure-based inhibitor discovery, failure to consider ligand solvation often leads to putative ligands that are too highly char...

This paper presents preliminary work on identification of argumentation schemes, i.e., identifying premises, conclusion and name of argumentation scheme, in arguments for scientific claims in genetics research articles. The goal is to develop annotation guidelines for creating corpora for argumentation mining research. This paper gives the specification of ten semantically distinct argumentatio...

T diffusion of the Internet and digital technologies has enabled many organizations to use the open-content production model to produce and disseminate knowledge. While several prior studies have shown that the open-content production model can lead to high-quality output in the context of uncontroversial and verifiable information, it is unclear whether this production model will produce any d...