Laxative drugs are usually organized according to their mode of action, i.e. bulk forming agents, stool softeners, lubricants, saline laxatives, stimulants including some combined formulations. Among them, bulk forming laxatives promote the mildest laxation. The popular bulk forming herbal laxatives in Thailand and Southeast Asian countries are dry fruits of hairy basil (Ocimum americanum) and ...

The pod of Cassia fistula Linn. has been used as a laxative drug in Thai traditional medicine for a long time. The pods and leaves contain anthraquinone aglycones and anthraquinone glycosides which are the active laxative form, while rhein is a major component. The degree of laxative potency is depended on the content of anthraquinone glycosides. This study determined the content of total anthr...

AIM To estimate whether laxatives prescribed for constipation in Parkinson's disease (PD) could moderate rigidity. Constipation predates diagnosis of PD by decades. Deposition of misfolded protein may begin in the gut, driven by dysbiosis. Successive antimicrobial exposures are associated with cumulative increase in rigidity, and rigidity has biological gradients on circulating leukocyte-subset...

Background Opioids are an effective treatment for moderate-to-severe pain. However, they are associated with a number of gastrointestinal side effects, most commonly constipation. Laxatives do not target the underlying mechanism of opioid-induced constipation (OIC), so many patients do not have their symptoms resolved. Fixed-dose prolonged-release (PR) oxycodone/naloxone (OXN) tablets contain t...

Objective: to describe the case of a Brazilian Amazon woman presenting macroscopic melanosis coli associated with the chronic use of laxative herbal teas. Case Report: a 48years-old woman was referred for evaluation of a diffuse abdominal pain, intestinal meteorism, gastric plenitude, eructation and chronic constipation. The patient confirmed the use of laxatives and herbal teas as auto-medicat...

BACKGROUND Little is known regarding the burden of opioid-induced constipation (OIC) among patients who suffer from cancer-related pain. METHODS A prospective longitudinal study was conducted among cancer patients in the United Kingdom (UK), Canada, and Germany, which included medical record data abstraction, Internet-based patient surveys, and physician surveys. Patients on daily opioid ther...

Though others may have found this question hard to swallow (ba-dum-tcchh!), having the strength to be open about this is admirable. Finding yourself with a case of the runs can certainly put a damper on your whole sexual experience. While a semen allergy is one possible cause of dicey bowels, such allergies are quite rare. Perhaps you?ll be relieved to hear that it?s more likely that your diarr...

Though others may have found this question hard to swallow (ba-dum-tcchh!), having the strength to be open about this is admirable. Finding yourself with a case of the runs can certainly put a damper on your whole sexual experience. While a semen allergy is one possible cause of dicey bowels, such allergies are quite rare. Perhaps you?ll be relieved to hear that it?s more likely that your diarr...

Though others may have found this question hard to swallow (ba-dum-tcchh!), having the strength to be open about this is admirable. Finding yourself with a case of the runs can certainly put a damper on your whole sexual experience. While a semen allergy is one possible cause of dicey bowels, such allergies are quite rare. Perhaps you?ll be relieved to hear that it?s more likely that your diarr...

Though others may have found this question hard to swallow (ba-dum-tcchh!), having the strength to be open about this is admirable. Finding yourself with a case of the runs can certainly put a damper on your whole sexual experience. While a semen allergy is one possible cause of dicey bowels, such allergies are quite rare. Perhaps you?ll be relieved to hear that it?s more likely that your diarr...