We examine the effect of a parameter λ used to calibrate how responsive randomization probabilities are to observed data in an adaptively randomized clinical trial. We define and motivate the parameter λ and demonstrate how varying this parameter effects the operating characteristics of example clinical trial designs.

To design adapted houses many things must be considered: standards and recommendations related to the eld of disabilities, capacities and incapacities of the persons, and wishes of the future resident. Considering all those constraints makes di cult to build such adapted living areas. Automatic layout generation simpli es the design task and decreases both design costs and study times. However,...

A perpendicular array PA,(t, k, u) is a n(y) by k array A of u distinct symbols, which satisfies: (i) every row of A contains k distinct symbols, (ii) for any t columns, and for any t distinct symbols, there are precisely 2 rows with the given symbols in the given columns. Such a structure may also be described as a A-uniform, t-homogeneous set of injective mappings from a k-set into a u-set. A...

• The assumption of independence of errors, i.e., error of an observation is not related to or depends upon that of another. This assumption is usually assured with the use of proper randomization procedure. However, if there is any systematic pattern in the arrangement of treatments from one replication to another, errors may be nonindependent. • The assumption of additive effects can be defin...

--Bounds on (C-A)/C for Mercury as a function of the uncertainty in the value of the obliquity are determined. The high precision of 1 of arc which is required for reasonable bounds on (C-A)/C cannot be obtained by either earth based observations or the television imagery of the Mariner 73 flyby. Among other methods discussed, one involving both landers and orbiters could determine unam2 biguou...

Preliminary layout design of buildings has a substantial effect on the ultimate design of structural components and accordingly influences the construction cost. Exploring structurally efficient forms and shapes during the conceptual design stage of a project can also facilitate the optimum integrated design of buildings. This paper presents an automated method of determining column layout desi...

Sensemaking of large graphs, specifically those with millions of nodes, is a crucial task in many fields. Automatic graph layout algorithms, augmented with real-time human-in-the-loop interaction, can potentially support sensemaking of large graphs. However, designing interactive algorithms to achieve this is challenging. In this paper, we tackle the scalability problem of interactive layout of...

In this paper, to cope with the stochastic dynamic (or multi-period) problem, two new quadratic assignment-based mathematical models corresponding to the dynamic and static approaches are developed. The product demands are presumed to be dependent uncertain variables with normal distribution having known expectation, variance, and covariance that change from one period to the next one, randomly...

In mining projects, all uncertainties associated with a project must be considered to determine the feasibility study. Grade uncertainty is one of the major components of technical uncertainty that affects the variability of the project. Geostatistical simulation, as a reliable approach, is the most widely used method to quantify risk analysis to overcome the drawbacks of the estimation methods...