Only 30% of alcoholics develop liver disease (ALD) suggesting that additional factors are needed. Endotoxin is one such factor, but its etiology is unclear. Since the gut is the main source of endotoxin, we sought to determine whether an increase in intestinal permeability (leaky gut) is required for alcohol-induced endotoxemia and liver injury and whether the gut leakiness is preventable. For ...

The gut microbiota has been studied and continues to be a developing area in the pathognomic development of metabolic diseases like diabetes. Treatment with diet changes, addition supplements prebiotics/probiotics, impact fecal microbial transplantation can correlated targeting changes dysbiosis. Understanding impacts various anti-hyperglycemic agents such as metformin implications post-bariatr...

OBJECTIVES Intestinal permeability (IPT) was investigated in patients with autism as well as in their first-degree relatives to investigate leaky gut hypothesis. Faecal calprotectin (FC) was also measured in patients with autism, either with or without gastrointestinal symptoms, and in their first-degree relatives. PATIENTS AND METHODS IPT results, assessed by means of the lactulose/mannitol ...

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Western diet (rich in highly refined sugar and fat) can induce a range of metabolic dysfunctions animals humans, including neuroinflammation cognitive function decline. Neuroinflammation impairment, two critical pathological characteristics Alzheimer's disease, have been closely associated with microbial alteration via the gut-brain axis. Thus, present study aimed to investigate influence 2-...