The reaction between hemoglobin (Hb) and NO* has been investigated thoroughly in recent years, but its mechanism is still a matter of substantial controversy. We have carried out a systematic study of the influence of the following factors on the yield of S-nitrosohemoglobin (SNO-Hb) generated from the reaction of NO* with oxy-, deoxy-, and metHb: 1) the volumetric ratio of the protein and the ...

RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that repleting NO bioactivity would restore RBC function. We report that S-nitrosohemoglobin (SNO-Hb)...

In the centrosymmetric title compound, [Cd(2)(C(13)H(12)NOS(2))(4)], pairs of dithio-carbamate ligands exhibit different structural functions. Each of the terminal ligands is bidentately coordinated to one Cd(II) atom and forms a planar four-membered CS(2)Cd chelate ring, whereas pairs of the tridentate bridging ligands link two neighbouring Cd(II) atoms, forming extended eight-membered C(2)S(4...