host genetic factors play a central role in determining the clinical phenotype of human diseases. association between two polymorphic loci in human genome, human leukocyte antigen (hla) and killer cell immunoglobulin-like receptors (kirs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. hence, defining the influence of genetic di...

leukocyte adhesion deficiency type 1 (lad 1) is an autosomal recessive hereditary disorder resulting from deficiency of cd18, characterized by recurrent bacterial infections. we report two consanguineous patients with leukocyte adhesion deficiency type 1( lad1). these two infant boy patients were referred to us, within a short period of time, with the complaints of recurrent infections at the a...

vascular adhesion protein-1 (vap-1) is an endothelial cell surface-expressed oxidase involved in leukocyte traffic. the adhesive function, and therefore leukocyte infiltration to different tissues, can be blocked by anti-vap-1 antibodies as well as small molecule vap-1 inhibitors. several papers have been published on the effect of vap-1 blockade on both leukocyte accumulation into tumors and n...

Background: Recurrent spontaneous abortion (RSA) is defined as three or more se-quential abortions before the twentieth week of gestation. There are evidences to sup-port an allo-immunologic mechanism for RSA. One of the methods for treatment of RSA is leukocyte therapy; however there is still controversy about effectiveness of this method. Objectives: To evaluate the effectiveness of leukocyte...

The results of a study the wound healing activity composition based on hydrogel polyhexamethylene guanidine hydrochloride and Bergenia crassifolia extract, under conditions modeling thermal burns in laboratory animals (rats), are presented. It was found that affects change summary antioxidant leukocyte towards normalization these indicators. Morphological analysis slices showed that, influence ...

The molecular mechanisms underlying leukocyte recruitment in large arteries have been extensively studied using histological techniques on fixed tissues. However, there are no reports that address the dynamics of leukocyte recruitment in large arteries in vivo. We developed an intravital microscopy technique for direct observation of leukocyte-endothelium interactions in the mouse aorta. Circul...

background: dendritic cells (dcs) are the most potent stimulators of primary t cell responses and play a key role in immune reactions after stem cell transplantation. very little is known about the cord blood (cb) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after cb transplantation.   objectives: the aim of this stud...

conclusions the use of leukocyte esterase urine dipstick test can be a quick and easy method in early diagnosis of sbp to start the treatment until preparation of sbp-cell count results. results in this study, 100 patients with ascites due to cirrhosis, with an average age of 38.9 ± 6.54 years were evaluated. twenty cases had positive results, of whom 17 cases were also detected based on the st...