This study evaluates the impact of pre-discovery licensing on innovation and product market efficiency. Pre-discovery licensing is a form of R&D cooperation between firms, which accounts for more than 95% of all research collaborations. Pre-discovery licensing is pursued independently between firms, i.e., without governmental support. In contrast, in a research joint venture firms cooperate in ...

Killer cell immunoglobulin-like receptor/HLA class I (KIR/HLA-I) combinations are associated with disease risk, implicating functional roles for NK cells (NKCs) or KIR(+) T cells. KIR/HLA-I interactions can act through inhibition of NKC activation by target cells and NKC licensing for greater intrinsic responsiveness. We compared licensing conferred by the weaker, HLA-C group 1/KIR2DL3, and the...

Cyclin-dependent kinases (CDKs) restrict DNA replication origin firing to once per cell cycle by preventing the assembly of prereplicative complexes (pre-RCs; licensing) outside of G1 phase. Paradoxically, under certain circumstances, CDKs such as cyclin E-cdk2 are also required to promote licensing. Here, we show that CDK phosphorylation of the essential licensing factor Cdc6 stabilizes it by ...

Like all DNA viruses, human cytomegalovirus (HCMV) infection is known to result in profound effects on host cell cycle. Infection of fibroblasts with HCMV is known to induce an advance in cell cycle through the G(0)-G(1) phase and then a subsequent arrest of cell cycle in early S-phase, presumably resulting in a cellular environment optimum for high levels of viral DNA replication whilst preclu...

In eukaryotic cells, the function of DNA replication licensing components (Cdc6 and Cdt1, among others) is crucial for cell proliferation and genome stability. However, little is known about their role in whole organisms and whether licensing control interfaces with differentiation and developmental programs. Here, we study Arabidopsis thaliana CDT1, its regulation, and the consequences of over...

This paper investigates the effect of different patent regimes on R&D investment and social welfare in a duopoly market with uncertain R&D process. We find that strong patent protection increases R&D investment of at least one firm but whether both firms’ R&D investment will be more under strong patent protection is ambiguous. While ex-ante welfare is more likely to be higher under strong paten...

Technology transactions, such as licensing and R&D based alliances, have been growing rapidly in recent years. Even as technology licensing has grown, so has patenting. Both trends foreshadow possibly profound changes in firms’ strategy. In this paper, we develop a simple structural model in which both patenting and licensing are jointly determined by factors such as patent effectiveness, the p...

AIM To investigate the opinions of newly licensed drivers towards the minimum age of car driver licensing, and reasons for getting a licence. METHOD The New Zealand Drivers Study (NZDS) is a prospective cohort study of 3992 newly licensed car drivers in New Zealand, recruited between 1 February 2006 and 31 January 2008 from driver licensing agencies and licensing courses throughout New Zealan...