10.1016/S1674-6384(14)60042-3 Licorice (the roots of Glycyrrhiza uralensis) is widely-used in Chinese herbal compound prescriptions for its functions of nourishing qi, alleviating pain, tonifying spleen and stomach, eliminating phlegm, relieving coughing, and harmonizing prescriptions. It contains more than 20 triterpenoids and approximately 300 flavonoids. In recent years, many studies have r...

Isoliquiritigenin (ILG) of licorice is a potential cancer chemopreventive agent. In this paper, response surface methodology (RSM) integrating with Box-Behnken design (BBD) was firstly employed to optimize the ILG extraction, which based on the single-factor experiments. According to analysis, the effect of extraction time and ethanol concentration on yields was significantly. The optimum value...

The long QT syndrome is characterized by the observed association of "torsade de pointes" and the prolongation of the QT interval on the electrocardiogram. Acquired long QT syndrome typically affects older individuals, being often associated with the action of some drugs. Hypokalemia is a frequent cause of QT lengthening on the electrocardiogram. Chronic assumption of licorice may be an unusual...

Antimicrobial and antioxidant activities of the leaf extract some cultivated Iranian licorice populations

Introduction Licorice could exhibit beneficial effect in the management of insomnia by regulating key modulators such as GABA and serotonin, we therefore aimed to study potentail hypnotic licorice extract, glycyrrhizin (GCZ), on underlying mechanisms. Material methods Mice were randomly grouped a Control group, GCZ (low) (high) group DZP with 8 mice each group. Sleep latency, sleep duration loc...

objective: aflatoxin is important in the food industry, in animal husbandry and the medical area; there are enormous negative economic impacts due to this toxin. numerous studies have researched extracts and plant compounds with the intent to reduce the growth of aflatoxin-producing organisms, inhibit toxin production and suppress the major toxin encoded genes (i.e., aflr) in these organisms. l...

Helicobacter pylori is the causative agent of gastritis and peptic ulcer disease. Eradication of H. pylori is hard to achieve and often require multiple antibiotics regimens. These regimens are quite expensive and have substantial side effects. Licorice is a traditional drug which is frequently used for gastric discomforts in Iran. The susceptibility of H. pylori to the extract of licorice has ...

Isolation of CYP72A154, a gene involved in glycyrrhizin biosynthesis pathway, Glycyrrhiza glabra L. (Iranian licorice)