Temozolomide (TMZ) is an alkylating chemotherapeutic agent that prolongs the survival of patients with glioblastoma. Clinical benefit is more prominent in patients with methylation of the O(6) -methyl-guanine DNA methyltransferase (MGMT) promoter. However, all patients eventually suffer from tumor progression because their tumors become resistant to TMZ. Here, we modeled acquired TMZ resistance...

The universality of the target theory of radiation-induced effects is challenged by observations on non-targeted effects such as bystander effects and genomic instability. Essential features of non-targeted effects are that they do not require direct nuclear exposure by radiation and they are particularly significant at low doses. This new evidence suggests a need for a new paradigm in radiatio...

Land surface temperature over the past decades has shown a faster warming trend during the night than during the day. Extremely low night temperatures have occurred frequently due to the influence of land-sea thermal difference, topography and climate change. This asymmetric night temperature change is expected to affect plant ecophysiology and growth, as the plant carbon consumption processes ...

Owing to the large x-ray attenuation coefficient, appropriate bandgap, high resistivity, and mobility-lifetime (μτ) product, binary II–VI semiconductor CdSe is a promising detection material it has exhibited excellent at room temperature (RT). For further improving characteristics of detectors, electrical properties single crystals (SCs) grown through pressure-assisted vertical Bridgman method ...

Hydrophilic nanotubes formed by lipid molecules have potential applications as platforms for chemical or biological events occurring in an attolitre volume inside a hollow cylinder. Here, we have integrated the lipid nanotubes (LNTs) by applying an AC electric field via plug-in electrode needles placed above a substrate. The off-chip assembly method has the on-demand adjustability of an electro...

This work presents the effects of low-LET radiations (electrons) on normal and modified cells DNA. The radiation-induced effects are assessed using the COMETassay. The results show that modified cells are more sensible to exposure than the normal ones. The dose-effect relationship follows a linear-no-threshold model suggested by BEIR VII.

We consider a version of the symmetric Anderson impurity model (compactified) which has a non-Fermi liquid weak coupling regime. We find that in the Majorana fermion representation the perturbation theory can be conveniently developed in terms of Pfaffian determinants and we use this formalism to calculate the impurity free energy, self energies, and vertex functions. We also derive expressions...

It is common practice to base carcinogenic risk assessment on the view that there is no threshold for chemical carcinogenesis. In this context, the threshold is defined as a dose below which no effects are observed. Analysis of epidemiological and experimental data on chemical carcinogenesis confirms that no thresholds have been demonstrated in human or animal studies, including the ED01 study ...

Resource degradation is a chief concern related to increased recreational of U.S. public lands. The Seven Leave No Trace (LNT) Principles are used educate visitors how reduce impacts. This study sought understand Great Smoky Mountains National Park (GRSM) hikers’ behavioral intent towards LNT practices. A quantitative questionnaire was measure participants’ based on 4 predictor variables: attit...