It has been known that linoleic acid is converted to arachidonic acid in the body, and its process has gradually become clear. However, it is still unknown to what compound arachidonic acid is changed. According to the report of Davis et all) arachidonic acid labeled with C14 is incorporated into docosapentaenoic acid (22:5•¢)4.7.10.13.16 in the body of albino rats. The author has previously re...

Dietary triglycerides containing predominantly poly-unsaturated fatty acids (PUFAs) are known to reduce plasma total and low density lipoprotein (LDL) cholesterol concentrations relative to triglycerides containing predominantly saturated fatty acids. However, there is little information regarding the independent effects of individual n-6 and n-3 PUFAs on LDL metabolism. The present studies wer...

The present study assessed the in vivo effects of fatty acids on inflammation and carcinogenesis in mice. Fifteen fatty acids were examined for their effects on the inhibitory effect of caffeine on 12-O-tetradecanoylphorbol-13acetate (TPA)-induced ear oedema in mice. Furthermore, linoleic acid was studied for its effects on the inhibitory effect of caffeine on carcinogenesis in mouse skin initi...

Puberty has a profound effect upon the biochemical composition of the testis. We previously demonstrated that puberty was accompanied by great increases in the content of docosahexaenoic acid (DHA; 22:6 n-3) and dihomogamma-linoleic acid (20:3 n-6) and decreases in arachidonic acid (AA; 20:4 n-6) in the phospholipids of testis. In this report, we analyze the composition of the phospholipid mole...

Administration of doses of linoleic acid (LA) up to 36 g/d in humans raised blood levels of linoleic acid but not of its metabolites. This is probably because the conversion of LA to gamma-linolenic acid (GLA) is slow and rate-limiting. We have found that administration of relatively small amounts of GLA, up to 360 mg/d, raises human blood levels of dihomogammalinolenic acid (DGLA) and arachido...

White button mushrooms (Agaricus bisporous) are a potential breast cancer chemopreventive agent, as they suppress aromatase activity and estrogen biosynthesis. Therefore, we evaluated the activity of mushroom extracts in the estrogen receptor-positive/aromatase-positive MCF-7aro cell line in vitro and in vivo. Mushroom extract decreased testosterone-induced cell proliferation in MCF-7aro cells ...

The effect of dietary a-linolenic acid intake on linoleic acid metabolism and prostaglandin (PG) biosynthesis was investigated in two groups of six healthy females (25-32 yr). They were given isocaloric formula diets (FD) containing linoleic acid at a constant intake (4% of calories), with different amounts of a-linolenic acid: 0% (FD4/0), 4% (FD4/4), 8% (FD4/8) (group I) and 12% (FD4/12) or 16...

di-cis-decadienyl structure are apparently required for maintenance of normal growth and reproduction (16). The commonly occurring fatty acids exhibiting this structural moiety are linoleic (18 :2w6)', linolenic (1 8:3w3), and arachidonic acids (20:4co6). Since they are not synthesized de novo, they have been termed the â€oeEFA's.†• 2 A dietary requirement for these fatty acids has been shown...

Phytic acid (PA) has been recognized as a potent antioxidant and inhibitor of iron-catalyzed hydroxyl radical formation under in vitro and in vivo conditions. Therefore, the aim of the present study was to investigate, with the use of HPLC/MS/MS, whether PA is capable of inhibiting linoleic acid autoxidation and Fe(II)/ascorbate-induced peroxidation, as well as Fe(II)/ascorbate-induced lipid pe...