The endoplasmic reticulum (ER) is an organelle present in most eukaryotic cells and plays a pivotal role in lipid metabolism. ER dysfunction, specifically ER stress (ERS), is a pathophysiological response involved in lipid metabolism and cardiovascular lesions. Therefore, suppression of ERS may improve lipid metabolic disorders and reduce cardiovascular risk. Herein, we focus on novel breakthro...

Under the endoscopic observation with magnification endoscopy and narrow-band imaging, one of the novel findings in gastric neoplasms is white opaque substance (WOS), which is a manifestation of intracellular accumulation of lipid droplets. To elucidate the significance of this WOS formation, detailed lipid metabolism should be understood in gastric membranes. Recently, expression profiles of l...

Background: Fatty acids are known to be critically important in multiple biological functions. Phospholipid fatty acids of follicular fluid, an important microenvironment for the development of oocytes, may contribute to the women’s fertility and the efficacy of assisted reproduction techniques. The aim of this study was to investigate the effect of fatty acid composition of follicular fluid ph...

Alzheimer’s disease (AD) is an age-associated disorder that leads to neurocognitive impairment. Its main pathological hallmarks include amyloid beta (Aβ) plaques and hyperphosphorylated tau forming intracellular neurofibrillary tangles (NFT). Hyperactivation of a tau-phosphorylating protein, cdk5 by its activator p25 has been shown to be associated with AD. Cdk5 is believed to be playing an imp...

Long underappreciated as important cellular organelles, lipid droplets are finally being recognized as dynamic structures with a complex and interesting biology. In light of this newfound respect, we discuss emerging views on lipid droplet biology and speculate on the major advances to come.