نتایج جستجو برای: lipid peroxidation

تعداد نتایج: 162051  

Journal: :iranian biomedical journal 0
nirjala laxmi madhikarmi kora rudraiah siddalinga murthy

background: iron deficiency anemia is one of the major causes of morbidity and mortality worldwide. evidences from epidemiological and clinical studies suggest a possible correlation between antioxidant levels and the anemic disease risk. the present work is to investigate antioxidant levels and lipid peroxidation in anemic patients. methods: a number of 30 patients (15 males and 15 females) we...

Journal: :FEBS letters 1987
G F Vile C C Winterbourn

The effects of ADP, ATP, citrate and EDTA on iron-dependent microsomal and liposomal lipid peroxidation, and on 59FeCl3 binding to the lipid membranes were measured. The aim was to test if initiation of lipid peroxidation is a site-specific mechanism requiring bound iron. In the absence of chelator, iron was bound to both membranes. EDTA and citrate removed the iron and inhibited peroxidation. ...

Journal: :Èlektronnaâ obrabotka materialov 2022

The paper discusses a theoretical model for the kinetics of process lipid peroxidation, which takes into account effect synergy vitamins E and C. Approximations are analyzed that make it possible to simplify system, taking peculiarities peroxidation. resulting is minimal adequately describes peroxidation at stages significant effective control this as whole.

Journal: :BMB reports 2010
Jung Hwan Yoon Myeong Seon Lee Jung Hoon Kang

Lipid peroxidation is known to be an important factor in the pathologies of many diseases associated with oxidative stress. We assessed the lipid peroxidation induced by the reaction of ferritin with H2O2. When linoleic acid micelles or phosphatidyl choline liposomes were incubated with ferritin and H2O2, lipid peroxidation increased in the presence of ferritin and H2O2 in a concentration-depen...

Journal: :iranian journal of toxicology 0
heena prajapati department of zoology, school of sciences, gujarat university, ahmedabad, india ramtej jayram verma department of zoology, school of sciences, gujarat university, ahmedabad, india

background: phthalates are a group of multifunctional chemicals. diethyl phthalate (dep) is one of the most frequently used phthalates in solvents and fixatives for numerous industrial products. method: the present experiment was designed to assess oxidative stress, if any, caused by diethyl phthalate. for this the homogenates of liver and kidney were treated with different concentrations ( 10-...

2015
Plamena R. Angelova Mathew H. Horrocks David Klenerman Sonia Gandhi Andrey Y. Abramov Mikhail S. Shchepinov

Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease. Here, we studied the effect of oligomeric α-Syn on one of the major markers of oxidative stress, lipid peroxidation, in primary co-cultures of neurons a...

1997
Jeong Heo Gwang-Ha Kim Kyoung-Seog Lee Won-Uk Go Hyung-Jun Ju Seung-Keun Park Chul-Soo Song Geun-Am Song Mong Cho Ung-Suk Yang Han-Kyu Moon Yong-Keun Kim

OBJECTIVES This study was undertaken to examine the effect of oxidant on lipid peroxidation and lethal cell injury in rat liver slices. METHODS t-Butylhydroperoxide (t-BHP) was employed as a model of an oxidant. The lipid peroxidation and lethal cell injury were estimated by measuring the formation of malondialdehyde (MDA) and lactate dehydrogenase (LDH) release, respectively. RESULTS t-BHP...

Journal: :The Biochemical journal 1982
R J Trotta S G Sullivan A Stern

Lipid peroxidation and haemoglobin degradation were the two extremes of a spectrum of oxidative damage in red cells exposed to t-butyl hydroperoxide. The exact position in this spectrum depended on the availability of glucose and the ligand state of haemoglobin. In red cells containing oxy- or carbonmono-oxy-haemoglobin, hexose monophosphate-shunt activity was mainly responsible for metabolism ...

Journal: :The Journal of biological chemistry 1990
P D Thomas M J Poznansky

Lipid peroxidation is known to affect the activity of several enzymes including microsomal enzymes such as glucose-6-phosphatase; but its effect on the enzymes of lipid biosynthesis has not been investigated. Glycerol-3-phosphate acyltransferase (GPAT) represents the first committed step and probably the rate limiting step in glycerolipid synthesis and thus may be a good candidate for study. Ra...

Journal: :Acta poloniae pharmaceutica 2007
Santanu Chakraborty Kunal Roy Chandana Sengupta

Non-steroidal anti-inflammatory drugs (NSAIDs) are common in alleviating pain, pyrexia and inflammation, in patients with rheumatoid arthritis and osteoarthritis. As these drugs are associated with high incidence of gastrointestinal ulceration, bleeding and kidney damage which may be linked with lipid peroxidation. our study was aimed to examine lipid peroxidation induction capacity of NSAIDs (...

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