Following complete pancreatectomy, chicks exhibit an excessive hypercholesterolemia wshen fed a diet containing cholesterol plus cottonseed oil. This inordinate hypercholesterolemia is accompanied by intensified atherogenesis, compared with unoperated controls on the same diet. Dietary neutral fat is essential for these excessive cholesterolemic and atherogenic responses. The possible significa...

We show that mice lacking the ATP-binding cassette transmembrane transporter ABCG1 show progressive and age-dependent severe pulmonary lipidosis that recapitulates the phenotypes of different respiratory syndromes in both humans and mice. The lungs of chow-fed Abcg1(-/-) mice, >6-months old, exhibit extensive subpleural cellular accumulation, macrophage, and pneumocyte type 2 hypertrophy, massi...

The metabolism of endogenous sphingomyelin labeled with 32P or [methyl-3H]choline and of exogenous [choline-methyl-3H], [32P]-, or [N-acyl-1-14C]sphingomyelin was studied in normal and Niemann-Pick Type A (NP-A) cultured fibroblasts. Despite a greater than 96% decrease in lysosomal sphingomyelinase activity in the NP-A cells, they were able to degrade endogenously produced [32P]- or [methyl-3H]...

Concentrations of four neutral glycosyl ceramides were determined in plasma and erythrocytes from nine hemizygous patients with Fabry's disease (a hereditary glycolipid lipidosis), from the sister of one of the patients, and from the heterozygous mother of another one. The concentration of a trihexosyl ceramide, galactosylgalactosylglucosyl ceramide, was elevated in plasma from the patients abo...

Dicranella pseudosubulata Müll Hal. ex Gangulee is a moss species and member of the Dicranaceae family, which known to harbour many secondary metabolites therapeutic importance. A gas chromatography-mass spectrometry (GC-MS) analysis methanolic extract D. was obtained determine moss. The chromatogram revealed 48 compounds, four compounds showed highest concentrations, constituting 73.86% all bi...

Administration of chloroquine o r 4,4'-bis(diethylaminoethoxy)a,P-diethyldiphenylethane (DH) to rats in oral doses of 100 mg/kg for 7 days causes phospholipid and cholesteryl ester accumulation i n liver. T o further characterize this drug-induced lipidosis, we have isolated and characterized the lipids of subcellular fractions from control rats and rats treated with chloroquine, DH, and Triton...

an adult common mynah ( acridotheres tristis ) was presented with severe signs of progressive depression , anorexia , debilitation , and also a history of moderate pododermatitis for the last two months . hepatomegally was diagnosed clinically and radio-logically . the bird died a couple of hours after referral . postmortem examination revealed typical liver enlargement with yellowish brown dis...