نتایج جستجو برای: lipidosis

تعداد نتایج: 260  

2005
Maureen C. Carroll,

L-Carnitine is an amino acid derivative required for the β-oxidation of long-chain fatty acids, a process necessary for deriving energy from fat. Carnitine deficiency has been shown to cause dilated cardiomyopathy in a small population of dogs, and effects of carnitine deficiency on other tissue are being explored. Preliminary evidence reveals that feline hepatic lipidosis may result from a rel...

Journal: :The British journal of ophthalmology 1973
B Harcourt, N Ashton,

The leucodystrophies are a heterogeneous group of inherited neurological disorders all characterized by progressive symmetrical demyelination without any marked inflam-matory response, causing loss of motor, sensory, and intellectual functions with an eventual fatal outcome. Included in the group are metachromatic leucodystrophy (sulphatide lipidosis), Krabbe's globoid cell leucodystrophy, Cana...

2012
Takuo Ishida,

Cats often have two or three inflammatory diseases concurrently, in the liver, pancreas and small intestine. This condition is called “feline triaditis”. Therefore, it is important to search for other illnesses even though a single disease is diagnosed. Also it is very important to control vomiting in cats since vomiting may aggravate the condition. What is triaditis? Triad means a combination ...

Journal: :iranian journal of nuclear medicine 1999
mohammad eftekhari, arsalan vakili, armaghan fard-esfahani, siamak derakhshan, mohsen saghari,

in spite of very high sensitivity, bone scan is quite nonspecific in evaluation of bony lesions. in interpretation of bone scan special attention to patient’s clinical presentation and correlation with other lab and imaging modalities should be paid. in this report a patient with erdheim chester disease a rare and unusual form of lipidosis is presented and the pattern of 99mtc-mdp bone scan and...

Journal: :Journal of cell science 2001
S Lusa, T S Blom, E L Eskelinen, E Kuismanen, J E Månsson, K Simons, E Ikonen,

In mammalian cells, cholesterol is thought to associate with sphingolipids to form lateral membrane domains termed rafts. Increasing evidence suggests that rafts regulate protein interactions, for example, during signalling, intracellular transport and host-pathogen interactions. Rafts are present in cholesterol-sphingolipid-enriched membranes, including early and recycling endosomes, but wheth...

2015
Satoshi Takasaki, Kunihiko Maeda, Kensuke Joh, Shu Yamakage, Sachiko Fukase, Toshiyuki Takahashi, Masayuki Suzuki, Akira Matsunaga, Takao Saito,

Lipoprotein glomerulopathy (LPG) is characterized by histopathological features showing intra-glomerular lipoprotein thrombi and type III hyperlipoproteinemia (HLP), with heterozygote mutation of apolipoprotein (apo) E gene. On the other hand, as another renal lipidosis with type III HLP, apoE2 homozygote-related glomerulopathy (apoE2-GN) showing foamy macrophages has been reported. The case of...

Journal: :The Journal of biological chemistry 2004
Aino-Liisa Mutka, Sari Lusa, Matts D Linder, Eija Jokitalo, Outi Kopra, Matti Jauhiainen, Elina Ikonen,

Astrocytes secrete cholesterol in lipoprotein particles. Here we show that primary murine embryonic astrocytes secrete endogenously synthesized cholesterol but also the cholesterol precursors desmosterol and lathosterol. In astrocyte membranes, desmosterol and cholesterol were the predominant sterols. Astrocytes derived from Niemann-Pick type C lipidosis (NPC1-/-) mice displayed late endosomal ...

2014
Ana I Arroyo, Paola G Camoletto, Laura Morando, Marco Sassoe-Pognetto, Maurizio Giustetto, Paul P Van Veldhoven, Edward H Schuchman, Maria D Ledesma,

Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary to develop therapies for these diseases. Here we describe sphingomyelin (SM) as a key modulator of the dendritic spine actin cytoskeleton. We show that increased SM levels in neurons of acid sphingomyelinase knock out mice (ASMko), which...

Journal: :Circulation research 1990
A N Orekhov, V V Tertov, S A Kudryashov, V N Smirnov,

A 72-hour incubation of cultured cells with blood sera or plasma of patients suffering from coronary heart disease (CHD) with angiographically assessed coronary atherosclerosis caused a threefold to fourfold elevation of intracellular cholesterol. An elevated cholesterol level in the cells precultured with patients' sera was retained several days after the removal of the examined serum from cul...

2003
Lokenga Badinga,

In dairy cattle, the period of transition from late pregnancy to early lactation is characterized by dramatic changes in nutrient demand that necessitate coordinated changes in body tissue metabolism to meet requirements of energy, glucose and amino acids by the mammary gland (Bauman and Curie, 1980; Bell, 1995; Overton et al., 2001). Failure of the transition cow to appropriately adjust her me...

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