Lipoprotein glomerulopathy (LPG) is characterized by histopathological features showing intra-glomerular lipoprotein thrombi and type III hyperlipoproteinemia (HLP), with heterozygote mutation of apolipoprotein (apo) E gene. On the other hand, as another renal lipidosis with type III HLP, apoE2 homozygote-related glomerulopathy (apoE2-GN) showing foamy macrophages has been reported. The case of...

Astrocytes secrete cholesterol in lipoprotein particles. Here we show that primary murine embryonic astrocytes secrete endogenously synthesized cholesterol but also the cholesterol precursors desmosterol and lathosterol. In astrocyte membranes, desmosterol and cholesterol were the predominant sterols. Astrocytes derived from Niemann-Pick type C lipidosis (NPC1-/-) mice displayed late endosomal ...

Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary to develop therapies for these diseases. Here we describe sphingomyelin (SM) as a key modulator of the dendritic spine actin cytoskeleton. We show that increased SM levels in neurons of acid sphingomyelinase knock out mice (ASMko), which...

A 72-hour incubation of cultured cells with blood sera or plasma of patients suffering from coronary heart disease (CHD) with angiographically assessed coronary atherosclerosis caused a threefold to fourfold elevation of intracellular cholesterol. An elevated cholesterol level in the cells precultured with patients' sera was retained several days after the removal of the examined serum from cul...

In dairy cattle, the period of transition from late pregnancy to early lactation is characterized by dramatic changes in nutrient demand that necessitate coordinated changes in body tissue metabolism to meet requirements of energy, glucose and amino acids by the mammary gland (Bauman and Curie, 1980; Bell, 1995; Overton et al., 2001). Failure of the transition cow to appropriately adjust her me...

The hypothesis that C60 fullerene nanoparticles (C60) exert an antagonistic interactive effect on the toxicity of benzo[a]pyrene (BaP) has been supported by this investigation. Mussels were exposed to BaP (5, 50 & 100 ?g/L) and (C60–1 mg/L) separately in combination. Both shown co-localize secondary lysosomes hepatopancreatic digestive cells gland where they reduced lysosomal membrane stability...

Leucocytozoonosis was found in three layer farms in chickens with suspected fatty liver or fatty liver hemorrhagic syndrome in Korea between 2009 and 2011. These layer chicken flocks showed both mortality and decreased egg production for one or two weeks when they were between 59 and 82 weeks old. At the necropsy, the most prominent gross lesions were found in the liver, which was enlarged, had...

ERTAIN ASPECTS of dietary magnesium deficiency have been studied extensively in the rat and less so in the guinea pig, catf, duck, and dog. Excellent reviews of magnesium metabolism and requirement have been published by Wacker and Vallee 1 and O'Dell. 2 Magnesium deficiency results in calcification of the heart and kidney. High dietary magnesium has been shown to diminish the amount of cardiov...